Mycousfurans A and B, antibacterial usnic acid congeners from the fungus Mycosphaerella sp., isolated from a marine sediment

Jihye Lee, Jusung Lee, Geum Jin Kim, Inho Yang, Weihong Wang, Joo Won Nam, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Mycousfurans (1 and 2), two new usnic acid congeners, along with (−)-mycousnine (3), (−)-placodiolic acid (4), and (+)-usnic acid (5), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of Mycosphaerella sp. isolated from a marine sediment. The planar structures of 1 and 2 were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of 1 and 2 were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were found to have antibacterial activity, showing moderate activity against Kocuria rhizophila and Staphylococcus aureus.

Original languageEnglish
Article number422
JournalMarine Drugs
Volume17
Issue number7
DOIs
StatePublished - 19 Jul 2019

Keywords

  • Antibacterial activity
  • Mycosphaerella sp
  • Mycousfurans
  • Mycousnine
  • Placodiolic acid
  • Usnic acid

Fingerprint

Dive into the research topics of 'Mycousfurans A and B, antibacterial usnic acid congeners from the fungus Mycosphaerella sp., isolated from a marine sediment'. Together they form a unique fingerprint.

Cite this