Multivitamin and mineral supplementation containing phytonutrients scavenges reactive oxygen species in healthy subjects: A randomized, double-blinded, placebo-controlled trial

Seunghee Kang, Yeni Lim, You Jin Kim, Eun Sung Jung, Dong Ho Suh, Choong Hwan Lee, Eunmi Park, Jina Hong, Rodney A. Velliquette, Oran Kwon, Ji Yeon Kim

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites.

Original languageEnglish
Article number101
JournalNutrients
Volume11
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • Antioxidant capacity
  • DNA damage
  • Human clinical study
  • Phytonutrients
  • ROS scavenging

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