Multiplexed photoluminescent sensors: Towards improved disease diagnostics

Xiao Peng He, Xi Le Hu, Tony D. James, Juyoung Yoon, He Tian

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations


The ability to simultaneously monitor multiple analytes in, for example, a single microplate well, is important for both basic research and clinical applications. In particular, for disease diagnosis there is a growing awareness that determination of a single disease biomarker is insufficient to pathologically confirm a disease state. Consequently, much recent literature has been directed towards the development of multiplexed photoluminescent sensors which can simultaneously detect multiple and diverse biomarkers that exist in a homogenous solution or a single cell, accelerating the progress towards precise disease diagnosis. This tutorial review highlights a selection of recent contributions towards this emerging interdisciplinary field that incorporates chemistry, chemical biology, materials sciences and medical sciences.

Original languageEnglish
Pages (from-to)6687-6696
Number of pages10
JournalChemical Society Reviews
Issue number22
StatePublished - 21 Nov 2017

Bibliographical note

Funding Information:
Prof. Hong-Yang Wang and Dr Yu-Fei Pan, collaborators of Prof. He Tian and Dr Xiao-Peng He in the development of new molecular probes and sensors for cancer diagnosis, at the Eastern Hepatobiliary Surgery Institute of the Second Military Medical University are warmly thanked for their helpful discussion on the clinical aspects of this review. The authors are financially supported by the 973 project (2013CB733700), the Science and Technology Commission of Shanghai Municipality (15540723800), the National Natural Science Foundation of China (21722801 and 21572058), the Fundamental Research Funds for the Central Universities (222201717003) and the Shanghai Rising-Star Program (16QA1401400) (to X.-P. He). J. Y. thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities. T. D. J. thanks ECUST for a guest professorship.

Publisher Copyright:
© 2017 The Royal Society of Chemistry.


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