Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim, Hwanbum Lee, Keun Sang Oh, Seho Kweon, Ok cheol Jeon, Youngro Byun, Kwangmeyung Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yuk

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

Original languageEnglish
Pages (from-to)8444-8449
Number of pages6
Issue number33
StatePublished - Nov 2013

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).


  • Core/shell nanoparticles
  • Layer-by-layer approach
  • Lipid bilayers
  • Pluronics
  • Sustained delivery of exenatide


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