Multidimensional noise reduction in C-arm cone-beam CT via 2D-based Landweber iteration and 3D-based deep neural networks

Dahim Choi, Juhee Kim, Seung Hoon Chae, Byeongjoon Kim, Jongduk Baek, Andreas Maier, Rebecca Fahrig, Hyun Seok Park, Jang Hwan Choi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations


Recently, the necessity of using low-dose CT imaging with reduced noise has come to the forefront due to the risks involved in radiation. In order to acquire a high-resolution image from a low-resolution image which produces a relatively small amount of radiation, various algorithms including deep learning-based methods have been proposed. However, the current techniques have shown limited performance, especially with regard to losing fine details and blurring high-frequency edges. To enhance the previously suggested 2D patch-based denoising model, we have suggested the 3D block-based REDCNN model, employing convolution layers paired with deconvolution layers, shortcuts, and residual mappings. This process allows us to preserve the image structure and diagnostic features of an image, increasing image resolution by smoothing noise. Finally, we applied a bilateral filter in 3D and utilized a 2D-based Landweber iteration method to reduce remaining noise under a certain amplitude and prevent the edges from blurring. As a result, our proposed method effectively reduced Poisson noise level without losing diagnostic features and showed high performance in both qualitative and quantitative evaluation methods compared to ResNet2D, ResNet3D, REDCNN2D, and REDCNN3D.

Original languageEnglish
Title of host publicationMedical Imaging 2019
Subtitle of host publicationPhysics of Medical Imaging
EditorsTaly Gilat Schmidt, Guang-Hong Chen, Hilde Bosmans
ISBN (Electronic)9781510625433
StatePublished - 2019
EventMedical Imaging 2019: Physics of Medical Imaging - San Diego, United States
Duration: 17 Feb 201920 Feb 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2019: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego

Bibliographical note

Publisher Copyright:
© SPIE. Downloading of the abstract is permitted for personal use only.


  • Bilateral filtering
  • C-arm cone-beam CT
  • Deep neural networks
  • Imaging of lower extremities
  • Landweber type iteration
  • Medical image processing
  • Noise reduction


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