Multicenter study of the treatment of erectile dysfunction with transurethral alprostadil (MUSE) in Korea

S. C. Kim, T. Y. Ahn, H. K. Choi, N. G. Choi, T. G. Chung, W. S. Chung, T. K. Hwang, J. S. Hyun, G. W. Jung, C. I. Kim, J. J. Kim, S. W. Kim, C. H. Lee, K. S. Lee, W. H. Lee, K. S. Min, K. H. Moon, J. S. Paick, K. S. Park, N. C. ParkY. K. Park, J. K. Seo, K. K. Seo, J. S. Shin, Y. R. Yoon, W. C. Lee

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


A Korean multicenter study was conducted to assess the effectiveness of transurethral alprostadil with MUSE in 334 subjects with chronic erectile dysfunction (ED) who were enrolled in 21 clinical centers. Patients with psychogenic impotence comprised about 30% of subjects. Intraurethral alprostadil was titrated in a stepwise fashion in the clinics from 250 to 500 or 1000 mcg based on erectile response and tolerability. The erectile responses were evaluated using an erection assessment scale (score of 1-5). The dose that produced a maximal penile response of score 5 (full rigid erection) or 4 (full tumescence, partial rigidity) was selected for home treatment. Patients who showed partial erection (score of 3) with 1000 mcg were also included in the home-treatment group. In-clinic phase: 198 men (59.3%) had maximal penile responses of score 4 or 5. The rate of maximal responses was not related to patient age, etiology or duration of the ED. A total of 228 (68.3%) men progressed to home treatment. The overall level of comfort of the transurethral alprostadil was rated as uncomfortable or very uncomfortable in 12%. Home phase: During the two-month period of home treatment, 178 (78.1%) men had successful sexual intercourse at least once, and 78.2% of administrations (1976) resulted in successful intercourse. The main causes of drop-out were insufficient erectile response in 27 men (11.8%), adverse reactions (mostly penile or urethral pain) in 7 (3.1%) or both in 7 (3.1%). In conclusion, transurethral alprostadil could be a suitable treatment option for patients with ED regardless of age and etiology of ED. Efficacy in an Asian population (Korea) is comparable to that reported previously in Caucasians.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalInternational Journal of Impotence Research
Issue number2
StatePublished - 2000

Bibliographical note

Funding Information:
This study was supported in part by a grant from Janssen Korea Ltd.


  • Efficacy
  • Erectile dysfunction
  • Safety
  • Transurethral alprostadil


Dive into the research topics of 'Multicenter study of the treatment of erectile dysfunction with transurethral alprostadil (MUSE) in Korea'. Together they form a unique fingerprint.

Cite this