Multi-core vesicle nanoparticles for controlled delivery of protein drug

Soon Hong Yuk; Keun Sang Oh; Seung Ki Kim; Jin Ho Lee; Sun Hang Cho; Kwangmeyung Kim; Hyesung Jeon; Ick Chan Kwon

doi:10.1007/s13233-012-0053-y

Multi-core vesicle nanoparticles for controlled delivery of protein drug

Soon Hong Yuk
, Keun Sang Oh
, Seung Ki Kim
, Jin Ho Lee
, Sun Hang Cho
, Kwangmeyung Kim
, Hyesung Jeon
, Ick Chan Kwon

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

Original language	English
Pages (from-to)	309-312
Number of pages	4
Journal	Macromolecular Research
Volume	20
Issue number	3
DOIs	https://doi.org/10.1007/s13233-012-0053-y
State	Published - Mar 2012

Keywords

Human growth hormone
Multi-core vesicle NPs
Peptide drug
Pluronic/PEG composite NPs
Sustained release

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10.1007/s13233-012-0053-y

Cite this

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title = "Multi-core vesicle nanoparticles for controlled delivery of protein drug",

abstract = "The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.",

keywords = "Human growth hormone, Multi-core vesicle NPs, Peptide drug, Pluronic/PEG composite NPs, Sustained release",

author = "Yuk, \{Soon Hong\} and Oh, \{Keun Sang\} and Kim, \{Seung Ki\} and Lee, \{Jin Ho\} and Cho, \{Sun Hang\} and Kwangmeyung Kim and Hyesung Jeon and Kwon, \{Ick Chan\}",

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doi = "10.1007/s13233-012-0053-y",

language = "English",

volume = "20",

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journal = "Macromolecular Research",

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T1 - Multi-core vesicle nanoparticles for controlled delivery of protein drug

AU - Yuk, Soon Hong

AU - Oh, Keun Sang

AU - Kim, Seung Ki

AU - Lee, Jin Ho

AU - Cho, Sun Hang

AU - Kim, Kwangmeyung

AU - Jeon, Hyesung

AU - Kwon, Ick Chan

PY - 2012/3

Y1 - 2012/3

N2 - The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

AB - The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

KW - Human growth hormone

KW - Multi-core vesicle NPs

KW - Peptide drug

KW - Pluronic/PEG composite NPs

KW - Sustained release

UR - https://www.scopus.com/pages/publications/84862189747

U2 - 10.1007/s13233-012-0053-y

DO - 10.1007/s13233-012-0053-y

M3 - Article

AN - SCOPUS:84862189747

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VL - 20

SP - 309

EP - 312

JO - Macromolecular Research

JF - Macromolecular Research

IS - 3

ER -

Multi-core vesicle nanoparticles for controlled delivery of protein drug

Abstract

Keywords

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