Multi-core vesicle nanoparticles for controlled delivery of protein drug

Soon Hong Yuk; Keun Sang Oh; Seung Ki Kim; Jin Ho Lee; Sun Hang Cho; Kwangmeyung Kim; Hyesung Jeon; Ick Chan Kwon

doi:10.1007/s13233-012-0053-y

Multi-core vesicle nanoparticles for controlled delivery of protein drug

Soon Hong Yuk, Keun Sang Oh, Seung Ki Kim, Jin Ho Lee, Sun Hang Cho, Kwangmeyung Kim, Hyesung Jeon, Ick Chan Kwon

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

Original language	English
Pages (from-to)	309-312
Number of pages	4
Journal	Macromolecular Research
Volume	20
Issue number	3
DOIs	https://doi.org/10.1007/s13233-012-0053-y
State	Published - Mar 2012

Keywords

Human growth hormone
Multi-core vesicle NPs
Peptide drug
Pluronic/PEG composite NPs
Sustained release

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10.1007/s13233-012-0053-y

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abstract = "The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.",

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AU - Yuk, Soon Hong

AU - Oh, Keun Sang

AU - Kim, Seung Ki

AU - Lee, Jin Ho

AU - Cho, Sun Hang

AU - Kim, Kwangmeyung

AU - Jeon, Hyesung

AU - Kwon, Ick Chan

PY - 2012/3

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AB - The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

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Multi-core vesicle nanoparticles for controlled delivery of protein drug

Abstract

Keywords

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