Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Soon Hong Yuk; Keun Sang Oh; Heebeom Koo; Hyesung Jeon; Kwangmeyung Kim; Ick Chan Kwon

doi:10.1016/j.biomaterials.2011.07.017

Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Soon Hong Yuk, Keun Sang Oh, Heebeom Koo, Hyesung Jeon, Kwangmeyung Kim, Ick Chan Kwon

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology.

Original language	English
Pages (from-to)	7924-7931
Number of pages	8
Journal	Biomaterials
Volume	32
Issue number	31
DOIs	https://doi.org/10.1016/j.biomaterials.2011.07.017
State	Published - Nov 2011

Bibliographical note

Funding Information:
This work was financially supported by the Ministry of Science and Technology and grant from the fundamental R& D program for core technology of materials funded by the Ministry of Knowledge Economy, Republic of Korea .

Keywords

Chemotherapy
Docetaxel
Drug delivery
Multi-core vesicle nanoparticles
Pluronic

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10.1016/j.biomaterials.2011.07.017

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title = "Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs",

abstract = "The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology.",

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author = "Yuk, {Soon Hong} and Oh, {Keun Sang} and Heebeom Koo and Hyesung Jeon and Kwangmeyung Kim and Kwon, {Ick Chan}",

note = "Funding Information: This work was financially supported by the Ministry of Science and Technology and grant from the fundamental R& D program for core technology of materials funded by the Ministry of Knowledge Economy, Republic of Korea .",

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AU - Oh, Keun Sang

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AU - Jeon, Hyesung

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

N1 - Funding Information: This work was financially supported by the Ministry of Science and Technology and grant from the fundamental R& D program for core technology of materials funded by the Ministry of Knowledge Economy, Republic of Korea .

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N2 - The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology.

AB - The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology.

KW - Chemotherapy

KW - Docetaxel

KW - Drug delivery

KW - Multi-core vesicle nanoparticles

KW - Pluronic

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ER -

Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Abstract

Bibliographical note

Keywords

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