Multi-biomarker panel prediction model for diagnosis of pancreatic cancer

Doo Ho Lee, Woongchang Yoon, Areum Lee, Youngmin Han, Yoonhyeong Byun, Jae Seung Kang, Hongbeom Kim, Wooil Kwon, Young Ah Suh, Yonghwan Choi, Junghyun Namkung, Sangjo Han, Sung Gon Yi, Jin Seok Heo, In Woong Han, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Eunsung Jun, Chang Moo KangWoo Jin Lee, Hyeon Kook Lee, Huisong Lee, Seungyeoun Lee, Seung Yong Jeong, Kyu Eun Lee, Wonshik Han, Taesung Park, Jin Young Jang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background/Purpose: The current study aimed to develop a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic ductal adenocarcinoma. Methods: Multi-center cohort of 1991 blood samples were collected from January 2011 to September 2019, of which 609 were normal, 145 were other cancer (colorectal, thyroid, and breast cancer), 314 were pancreatic benign disease, and 923 were pancreatic ductal adenocarcinoma. The automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed using three potential biomarkers: LRG1, TTR, and CA 19-9. Using a logistic regression model on a training data set, the predicted values for pancreatic ductal adenocarcinoma were obtained, and the result was classification into one of the three risk groups: low, intermediate, and high. The five covariates used to create the model were sex, age, and three biomarkers. Results: Participants were categorized into four groups as normal (n = 609), other cancer (n = 145), pancreatic benign disease (n = 314), and pancreatic ductal adenocarcinoma (n = 923). The normal, other cancer, and pancreatic benign disease groups were clubbed into the non-pancreatic ductal adenocarcinoma group (n = 1068). The positive and negative predictive value, sensitivity, and specificity were 94.12, 90.40, 93.81, and 90.86, respectively. Conclusions: This study demonstrates a significant diagnostic performance of the multi-marker panel in distinguishing pancreatic ductal adenocarcinoma from normal and benign pancreatic disease states, as well as patients with other cancers.

Original languageEnglish
JournalJournal of Hepato-Biliary-Pancreatic Sciences
DOIs
StateAccepted/In press - 2021

Keywords

  • biomarker panel
  • diagnosis
  • pancreatic ductal adenocarcinoma
  • screening
  • tumor marker

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