Abstract
Effects of aqueous mulberry leaf extract (Morus alba L.) on glucose and lipid metabolisms in highfat and high-sucrose diet-induced overweight animal models were examined. Supplementation of mulberry leaf extract (MLE) resulted in body weight changes in both high-fat- and high-sucroseinduced overweight rats. Plasma insulin and Homeostasis model assessment-insulin resistance also significantly decreased by MLE treatment (p<0.05). In addition, plasma free fatty acid level was also decreased by MLE supplementation in high-fat diet-induced overweight rat (p<0.05). MLE supplementation significantly (p<0.05) increased the expression of insulin receptor genes at the transcriptional level. MLE supplementation decreased plasma insulin concentrations increased by high-fat or high-sucrose diets and improved insulin sensitivity by increasing the expression level of insulin receptor in muscle and adipose tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 612-618 |
| Number of pages | 7 |
| Journal | Journal of the Korean Society for Applied Biological Chemistry |
| Volume | 54 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2011 |
Keywords
- High fat diet
- High sucrose diet
- Insulin sensitivity
- Mulberry leaf extract
- Overweight