Mulberry leaf water extract ameliorates insulin sensitivity in high fat or high sucrose diet induced overweight rats

Ji Yeon Kim, Bong Gyeom Choi, Myung Ji Jung, Ji Hyang Wee, Kyoung Hee Chung, Oran Kwon

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Effects of aqueous mulberry leaf extract (Morus alba L.) on glucose and lipid metabolisms in highfat and high-sucrose diet-induced overweight animal models were examined. Supplementation of mulberry leaf extract (MLE) resulted in body weight changes in both high-fat- and high-sucroseinduced overweight rats. Plasma insulin and Homeostasis model assessment-insulin resistance also significantly decreased by MLE treatment (p<0.05). In addition, plasma free fatty acid level was also decreased by MLE supplementation in high-fat diet-induced overweight rat (p<0.05). MLE supplementation significantly (p<0.05) increased the expression of insulin receptor genes at the transcriptional level. MLE supplementation decreased plasma insulin concentrations increased by high-fat or high-sucrose diets and improved insulin sensitivity by increasing the expression level of insulin receptor in muscle and adipose tissue.

Original languageEnglish
Pages (from-to)612-618
Number of pages7
JournalJournal of the Korean Society for Applied Biological Chemistry
Volume54
Issue number4
DOIs
StatePublished - 2011

Keywords

  • High fat diet
  • High sucrose diet
  • Insulin sensitivity
  • Mulberry leaf extract
  • Overweight

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