Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: A randomized, double-blind placebo-controlled trial

Ji Yeon Kim, Hyang Mok Ok, Joohee Kim, Seok Won Park, Sung Won Kwon, Oran Kwon

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

This study was a randomized, double-blind placebo-controlled trial to assess the efficacy of 4 weeks of mulberry leaf aqueous extract (MLAE) supplementation (5g/day) for postprandial glycemic control in 36 subjects with impaired fasting glucose (IFG) tolerance. Postprandial responses in the glucose, insulin, and C-peptide levels were measured after a carbohydrate load both at baseline and after 4 weeks of MLAE supplementation. The postprandial glycemic response was attenuated in the MLAE group after the treatment period, particularly 30 and 60min after loading (P=.003 and 0.0325 for glucose, P=.0005 and .0350 for insulin, and P=.0151 and .0864 for C-peptide). Additionally, the incremental area under the curve for insulin was significantly lower in the MLAE group than in the placebo group (P=.0207). Four weeks of MLAE supplementation improved postprandial glycemic control in individuals with IFG tolerance.

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalJournal of Medicinal Food
Volume18
Issue number3
DOIs
StatePublished - 1 Mar 2015

Keywords

  • 1-deoxynojirimycin
  • mulberry leaf aqueous extract
  • postprandial glycemic control

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