Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects

Hyeonseok S. Jeong; Sunho Lee; Sujung Yoon; Jiyoung J. Jung; Han Byul Cho; Binna N. Kim; Jiyoung Ma; Eun Ko; Jooyeon Jamie Im; Soonhyun Ban; Perry F. Renshaw; In Kyoon Lyoo

doi:10.1016/j.drugalcdep.2013.05.009

Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects

Hyeonseok S. Jeong, Sunho Lee, Sujung Yoon, Jiyoung J. Jung, Han Byul Cho, Binna N. Kim, Jiyoung Ma, Eun Ko, Jooyeon Jamie Im, Soonhyun Ban, Perry F. Renshaw, In Kyoon Lyoo

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects. Methods: High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined. Results: Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus. Conclusions: Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity.

Original language	English
Pages (from-to)	222-229
Number of pages	8
Journal	Drug and Alcohol Dependence
Volume	131
Issue number	3
DOIs	https://doi.org/10.1016/j.drugalcdep.2013.05.009
State	Published - 1 Aug 2013

Bibliographical note

Funding Information:
IKL has received research support from Lundbeck, AstraZeneca, GSK, and Boryung Pharmaceutical. PFR has been a consultant for Ridge Diagnostics and Kyowa Hakko. Other authors report no financial relationships with commercial interests.

Funding Information:
This study was supported by a grant of the Korea Health technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A101219 ). The funding source of the study had no role in the study design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.

Keywords

Lateral ventricle
Methamphetamine
Neuroimaging
Surface-based morphometry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.drugalcdep.2013.05.009

Cite this

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title = "Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects",

abstract = "Background: The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects. Methods: High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined. Results: Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus. Conclusions: Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity.",

keywords = "Lateral ventricle, Methamphetamine, Neuroimaging, Surface-based morphometry",

author = "Jeong, {Hyeonseok S.} and Sunho Lee and Sujung Yoon and Jung, {Jiyoung J.} and Cho, {Han Byul} and Kim, {Binna N.} and Jiyoung Ma and Eun Ko and Im, {Jooyeon Jamie} and Soonhyun Ban and Renshaw, {Perry F.} and Lyoo, {In Kyoon}",

note = "Funding Information: IKL has received research support from Lundbeck, AstraZeneca, GSK, and Boryung Pharmaceutical. PFR has been a consultant for Ridge Diagnostics and Kyowa Hakko. Other authors report no financial relationships with commercial interests. Funding Information: This study was supported by a grant of the Korea Health technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A101219 ). The funding source of the study had no role in the study design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript. ",

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doi = "10.1016/j.drugalcdep.2013.05.009",

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journal = "Drug and Alcohol Dependence",

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T1 - Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects

AU - Jeong, Hyeonseok S.

AU - Lee, Sunho

AU - Yoon, Sujung

AU - Jung, Jiyoung J.

AU - Cho, Han Byul

AU - Kim, Binna N.

AU - Ma, Jiyoung

AU - Ko, Eun

AU - Im, Jooyeon Jamie

AU - Ban, Soonhyun

AU - Renshaw, Perry F.

AU - Lyoo, In Kyoon

N1 - Funding Information: IKL has received research support from Lundbeck, AstraZeneca, GSK, and Boryung Pharmaceutical. PFR has been a consultant for Ridge Diagnostics and Kyowa Hakko. Other authors report no financial relationships with commercial interests. Funding Information: This study was supported by a grant of the Korea Health technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A101219 ). The funding source of the study had no role in the study design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Background: The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects. Methods: High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined. Results: Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus. Conclusions: Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity.

AB - Background: The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects. Methods: High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined. Results: Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus. Conclusions: Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity.

KW - Lateral ventricle

KW - Methamphetamine

KW - Neuroimaging

KW - Surface-based morphometry

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JO - Drug and Alcohol Dependence

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IS - 3

ER -

Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects

Abstract

Bibliographical note

Keywords

UN SDGs

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