Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects

Hyeonseok S. Jeong, Sunho Lee, Sujung Yoon, Jiyoung J. Jung, Han Byul Cho, Binna N. Kim, Jiyoung Ma, Eun Ko, Jooyeon Jamie Im, Soonhyun Ban, Perry F. Renshaw, In Kyoon Lyoo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects. Methods: High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined. Results: Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus. Conclusions: Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity.

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalDrug and Alcohol Dependence
Issue number3
StatePublished - 1 Aug 2013

Bibliographical note

Funding Information:
IKL has received research support from Lundbeck, AstraZeneca, GSK, and Boryung Pharmaceutical. PFR has been a consultant for Ridge Diagnostics and Kyowa Hakko. Other authors report no financial relationships with commercial interests.

Funding Information:
This study was supported by a grant of the Korea Health technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A101219 ). The funding source of the study had no role in the study design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.


  • Lateral ventricle
  • Methamphetamine
  • Neuroimaging
  • Surface-based morphometry


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