Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Xiaosheng Liu; Shuang Zeng; Ming Zhang; Maojun Jiang; Yves S. Kafuti; Pingping Shangguan; Yichu Yu; Qixian Chen; Jingyun Wang; Xiaojun Peng; Juyoung Yoon; Haidong Li

doi:10.1039/d2cc04112j

Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Xiaosheng Liu
, Shuang Zeng
, Ming Zhang
, Maojun Jiang
, Yves S. Kafuti
, Pingping Shangguan
, Yichu Yu
, Qixian Chen
, Jingyun Wang
, Xiaojun Peng
, Juyoung Yoon
, Haidong Li

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

Original language	English
Pages (from-to)	11438-11441
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	81
DOIs	https://doi.org/10.1039/d2cc04112j
State	Published - 9 Sep 2022

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© 2022 The Royal Society of Chemistry.

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@article{83fc888e6acb4857a64fb0751acba36f,

title = "Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe",

abstract = "We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.",

author = "Xiaosheng Liu and Shuang Zeng and Ming Zhang and Maojun Jiang and Kafuti, \{Yves S.\} and Pingping Shangguan and Yichu Yu and Qixian Chen and Jingyun Wang and Xiaojun Peng and Juyoung Yoon and Haidong Li",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = sep,

day = "9",

doi = "10.1039/d2cc04112j",

language = "English",

volume = "58",

pages = "11438--11441",

journal = "Chemical Communications",

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TY - JOUR

T1 - Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

AU - Liu, Xiaosheng

AU - Zeng, Shuang

AU - Zhang, Ming

AU - Jiang, Maojun

AU - Kafuti, Yves S.

AU - Shangguan, Pingping

AU - Yu, Yichu

AU - Chen, Qixian

AU - Wang, Jingyun

AU - Peng, Xiaojun

AU - Yoon, Juyoung

AU - Li, Haidong

PY - 2022/9/9

Y1 - 2022/9/9

N2 - We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

AB - We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

UR - https://www.scopus.com/pages/publications/85139739759

U2 - 10.1039/d2cc04112j

DO - 10.1039/d2cc04112j

M3 - Article

C2 - 36135099

AN - SCOPUS:85139739759

SN - 1359-7345

VL - 58

SP - 11438

EP - 11441

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Abstract

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