Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Xiaosheng Liu, Shuang Zeng, Ming Zhang, Maojun Jiang, Yves S. Kafuti, Pingping Shangguan, Yichu Yu, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, Haidong Li

Research output: Contribution to journalArticlepeer-review

Abstract

We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

Original languageEnglish
Pages (from-to)11438-11441
Number of pages4
JournalChemical Communications
Volume58
Issue number81
DOIs
StatePublished - 9 Sep 2022

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