Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Xiaosheng Liu; Shuang Zeng; Ming Zhang; Maojun Jiang; Yves S. Kafuti; Pingping Shangguan; Yichu Yu; Qixian Chen; Jingyun Wang; Xiaojun Peng; Juyoung Yoon; Haidong Li

doi:10.1039/d2cc04112j

Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Xiaosheng Liu, Shuang Zeng, Ming Zhang, Maojun Jiang, Yves S. Kafuti, Pingping Shangguan, Yichu Yu, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, Haidong Li

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

Original language	English
Pages (from-to)	11438-11441
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	81
DOIs	https://doi.org/10.1039/d2cc04112j
State	Published - 9 Sep 2022

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© 2022 The Royal Society of Chemistry.

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@article{83fc888e6acb4857a64fb0751acba36f,

title = "Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe",

abstract = "We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.",

author = "Xiaosheng Liu and Shuang Zeng and Ming Zhang and Maojun Jiang and Kafuti, {Yves S.} and Pingping Shangguan and Yichu Yu and Qixian Chen and Jingyun Wang and Xiaojun Peng and Juyoung Yoon and Haidong Li",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = sep,

day = "9",

doi = "10.1039/d2cc04112j",

language = "English",

volume = "58",

pages = "11438--11441",

journal = "Chemical Communications",

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TY - JOUR

T1 - Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

AU - Liu, Xiaosheng

AU - Zeng, Shuang

AU - Zhang, Ming

AU - Jiang, Maojun

AU - Kafuti, Yves S.

AU - Shangguan, Pingping

AU - Yu, Yichu

AU - Chen, Qixian

AU - Wang, Jingyun

AU - Peng, Xiaojun

AU - Yoon, Juyoung

AU - Li, Haidong

PY - 2022/9/9

Y1 - 2022/9/9

N2 - We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

AB - We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

UR - http://www.scopus.com/inward/record.url?scp=85139739759&partnerID=8YFLogxK

U2 - 10.1039/d2cc04112j

DO - 10.1039/d2cc04112j

M3 - Article

C2 - 36135099

AN - SCOPUS:85139739759

SN - 1359-7345

VL - 58

SP - 11438

EP - 11441

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Abstract

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