Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging

Sinyoung Park, Eun Yeong Park, Nahyun Kwon, Kwang H. Kim, Yejin Cho, Junha Lim, Seda Çetindere, Süreyya Oğuz Tümay, Won Jong Kim, Xingshu Li, Ki Taek Nam, Serkan Yeşilot, Juyoung Yoon, Chulhong Kim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Photoacoustic imaging has begun to be widely used to observe drug delivery and accumulation in the body. Theranostic, which includes both diagnosis and therapy, is an attractive approach for treating cancer. In this study, we synthesized nanomaterials and verified the theranostic effect through fluorescence and photoacoustic imaging. Selectively transporting a drug to the tumor site is essential to increase the therapeutic effect while reducing side effects. BODIPY has the advantages of being able to change its structure more easily, good photostability, good biocompatibility and high absorption coefficient than cyanine or porphyrin dyes, however they are limited to in vivo experiment due to their poor water solubility. We overcome the limitations of BODIPY-based materials by encapsulating in micellar nanoparticles with Hexa BODIPY cyclophosphazene (HBCP) and DSPE-PEG2000 polymer. HBCP NPs also have a property of selectively accumulating in tumors with enhanced permeability and retention effect due to their bulky nano-size molecular structure. We checked the tumor targeting and retention time of HBCP NPs by monitoring them with fluorescence imaging. In addition, the high heat conversion efficiency of HBCP NPs enables photoacoustic imaging and Photothermal therapy. We also conducted whole body scanning of tail-vein injected tumor-bearing mice with acoustic resolution photoacoustic microscopy system to provide tumor accumulation information of HBCP NP with vascular structure. The result suggests that HBCP NP has a potential to be used as a material for image guided phototherapy.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2023
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781510658639
StatePublished - 2023
EventPhotons Plus Ultrasound: Imaging and Sensing 2023 - San Francisco, United States
Duration: 29 Jan 20231 Feb 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2023
Country/TerritoryUnited States
CitySan Francisco

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation of Korea (NRF) funded by the Korea Medical Device Development Fund grant funded by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (9991007019, KMDF_PR_20200901_0008); by the Ministry of Education (2020R1A6A1A03047902, 2021R1A6A3A13044749); by the Ministry of Science and ICT (2019R1A2C2006269); Ministry of Science and ICT (2020M3H2A1078045, 2021M3C1C3097624); by Institute of Information & communications Technology Planning & Evaluation (IITP) grant funded by the Korea government(MSIT) (No.2019-0-01906, Artificial Intelligence Graduate School Program(POSTECH)) and Korea Evaluation Institute of Industrial Technology(KEIT) grant funded by the Korea government(MOTIE) and by the BK21 FOUR project.

Publisher Copyright:
© 2023 SPIE.


  • drug delivery
  • Photoacoustic
  • photoacoustic microscopy
  • tumor-targeting drug


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