Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging

Sinyoung Park; Eun Yeong Park; Nahyun Kwon; Kwang H. Kim; Yejin Cho; Junha Lim; Seda Çetindere; Süreyya Oğuz Tümay; Won Jong Kim; Xingshu Li; Ki Taek Nam; Serkan Yeşilot; Juyoung Yoon; Chulhong Kim

doi:10.1117/12.2648142

Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging

Sinyoung Park, Eun Yeong Park, Nahyun Kwon, Kwang H. Kim, Yejin Cho, Junha Lim, Seda Çetindere, Süreyya Oğuz Tümay, Won Jong Kim, Xingshu Li, Ki Taek Nam, Serkan Yeşilot, Juyoung Yoon, Chulhong Kim

Department of Chemistry & Nanoscience

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Photoacoustic imaging has begun to be widely used to observe drug delivery and accumulation in the body. Theranostic, which includes both diagnosis and therapy, is an attractive approach for treating cancer. In this study, we synthesized nanomaterials and verified the theranostic effect through fluorescence and photoacoustic imaging. Selectively transporting a drug to the tumor site is essential to increase the therapeutic effect while reducing side effects. BODIPY has the advantages of being able to change its structure more easily, good photostability, good biocompatibility and high absorption coefficient than cyanine or porphyrin dyes, however they are limited to in vivo experiment due to their poor water solubility. We overcome the limitations of BODIPY-based materials by encapsulating in micellar nanoparticles with Hexa BODIPY cyclophosphazene (HBCP) and DSPE-PEG2000 polymer. HBCP NPs also have a property of selectively accumulating in tumors with enhanced permeability and retention effect due to their bulky nano-size molecular structure. We checked the tumor targeting and retention time of HBCP NPs by monitoring them with fluorescence imaging. In addition, the high heat conversion efficiency of HBCP NPs enables photoacoustic imaging and Photothermal therapy. We also conducted whole body scanning of tail-vein injected tumor-bearing mice with acoustic resolution photoacoustic microscopy system to provide tumor accumulation information of HBCP NP with vascular structure. The result suggests that HBCP NP has a potential to be used as a material for image guided phototherapy.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2023
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781510658639
DOIs	https://doi.org/10.1117/12.2648142
State	Published - 2023
Event	Photons Plus Ultrasound: Imaging and Sensing 2023 - San Francisco, United States Duration: 29 Jan 2023 → 1 Feb 2023

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12379
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2023
Country/Territory	United States
City	San Francisco
Period	29/01/23 → 1/02/23

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation of Korea (NRF) funded by the Korea Medical Device Development Fund grant funded by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (9991007019, KMDF_PR_20200901_0008); by the Ministry of Education (2020R1A6A1A03047902, 2021R1A6A3A13044749); by the Ministry of Science and ICT (2019R1A2C2006269); Ministry of Science and ICT (2020M3H2A1078045, 2021M3C1C3097624); by Institute of Information & communications Technology Planning & Evaluation (IITP) grant funded by the Korea government(MSIT) (No.2019-0-01906, Artificial Intelligence Graduate School Program(POSTECH)) and Korea Evaluation Institute of Industrial Technology(KEIT) grant funded by the Korea government(MOTIE) and by the BK21 FOUR project.

Publisher Copyright:
© 2023 SPIE.

Keywords

drug delivery
Photoacoustic
photoacoustic microscopy
tumor-targeting drug

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.2648142

Cite this

Park, S., Park, E. Y., Kwon, N., Kim, K. H., Cho, Y., Lim, J., Çetindere, S., Tümay, S. O., Kim, W. J., Li, X., Nam, K. T., Yeşilot, S., Yoon, J., & Kim, C. (2023). Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2023 Article 123791F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12379). SPIE. https://doi.org/10.1117/12.2648142

@inproceedings{2abc9e86c7fe47a7a7b495842da52df3,

title = "Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging",

abstract = "Photoacoustic imaging has begun to be widely used to observe drug delivery and accumulation in the body. Theranostic, which includes both diagnosis and therapy, is an attractive approach for treating cancer. In this study, we synthesized nanomaterials and verified the theranostic effect through fluorescence and photoacoustic imaging. Selectively transporting a drug to the tumor site is essential to increase the therapeutic effect while reducing side effects. BODIPY has the advantages of being able to change its structure more easily, good photostability, good biocompatibility and high absorption coefficient than cyanine or porphyrin dyes, however they are limited to in vivo experiment due to their poor water solubility. We overcome the limitations of BODIPY-based materials by encapsulating in micellar nanoparticles with Hexa BODIPY cyclophosphazene (HBCP) and DSPE-PEG2000 polymer. HBCP NPs also have a property of selectively accumulating in tumors with enhanced permeability and retention effect due to their bulky nano-size molecular structure. We checked the tumor targeting and retention time of HBCP NPs by monitoring them with fluorescence imaging. In addition, the high heat conversion efficiency of HBCP NPs enables photoacoustic imaging and Photothermal therapy. We also conducted whole body scanning of tail-vein injected tumor-bearing mice with acoustic resolution photoacoustic microscopy system to provide tumor accumulation information of HBCP NP with vascular structure. The result suggests that HBCP NP has a potential to be used as a material for image guided phototherapy.",

keywords = "drug delivery, Photoacoustic, photoacoustic microscopy, tumor-targeting drug",

author = "Sinyoung Park and Park, {Eun Yeong} and Nahyun Kwon and Kim, {Kwang H.} and Yejin Cho and Junha Lim and Seda {\c C}etindere and T{\"u}may, {S{\"u}reyya Oğuz} and Kim, {Won Jong} and Xingshu Li and Nam, {Ki Taek} and Serkan Ye{\c s}ilot and Juyoung Yoon and Chulhong Kim",

note = "Funding Information: This study was supported by the National Research Foundation of Korea (NRF) funded by the Korea Medical Device Development Fund grant funded by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (9991007019, KMDF_PR_20200901_0008); by the Ministry of Education (2020R1A6A1A03047902, 2021R1A6A3A13044749); by the Ministry of Science and ICT (2019R1A2C2006269); Ministry of Science and ICT (2020M3H2A1078045, 2021M3C1C3097624); by Institute of Information & communications Technology Planning & Evaluation (IITP) grant funded by the Korea government(MSIT) (No.2019-0-01906, Artificial Intelligence Graduate School Program(POSTECH)) and Korea Evaluation Institute of Industrial Technology(KEIT) grant funded by the Korea government(MOTIE) and by the BK21 FOUR project. Publisher Copyright: {\textcopyright} 2023 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2023 ; Conference date: 29-01-2023 Through 01-02-2023",

year = "2023",

doi = "10.1117/12.2648142",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",

booktitle = "Photons Plus Ultrasound",

}

Park, S, Park, EY, Kwon, N, Kim, KH, Cho, Y, Lim, J, Çetindere, S, Tümay, SO, Kim, WJ, Li, X, Nam, KT, Yeşilot, S, Yoon, J & Kim, C 2023, Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2023., 123791F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12379, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2023, San Francisco, United States, 29/01/23. https://doi.org/10.1117/12.2648142

Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging. / Park, Sinyoung; Park, Eun Yeong; Kwon, Nahyun et al.
Photons Plus Ultrasound: Imaging and Sensing 2023. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2023. 123791F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12379).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging

AU - Park, Sinyoung

AU - Park, Eun Yeong

AU - Kwon, Nahyun

AU - Kim, Kwang H.

AU - Cho, Yejin

AU - Lim, Junha

AU - Çetindere, Seda

AU - Tümay, Süreyya Oğuz

AU - Kim, Won Jong

AU - Li, Xingshu

AU - Nam, Ki Taek

AU - Yeşilot, Serkan

AU - Yoon, Juyoung

AU - Kim, Chulhong

N1 - Funding Information: This study was supported by the National Research Foundation of Korea (NRF) funded by the Korea Medical Device Development Fund grant funded by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (9991007019, KMDF_PR_20200901_0008); by the Ministry of Education (2020R1A6A1A03047902, 2021R1A6A3A13044749); by the Ministry of Science and ICT (2019R1A2C2006269); Ministry of Science and ICT (2020M3H2A1078045, 2021M3C1C3097624); by Institute of Information & communications Technology Planning & Evaluation (IITP) grant funded by the Korea government(MSIT) (No.2019-0-01906, Artificial Intelligence Graduate School Program(POSTECH)) and Korea Evaluation Institute of Industrial Technology(KEIT) grant funded by the Korea government(MOTIE) and by the BK21 FOUR project. Publisher Copyright: © 2023 SPIE.

PY - 2023

Y1 - 2023

N2 - Photoacoustic imaging has begun to be widely used to observe drug delivery and accumulation in the body. Theranostic, which includes both diagnosis and therapy, is an attractive approach for treating cancer. In this study, we synthesized nanomaterials and verified the theranostic effect through fluorescence and photoacoustic imaging. Selectively transporting a drug to the tumor site is essential to increase the therapeutic effect while reducing side effects. BODIPY has the advantages of being able to change its structure more easily, good photostability, good biocompatibility and high absorption coefficient than cyanine or porphyrin dyes, however they are limited to in vivo experiment due to their poor water solubility. We overcome the limitations of BODIPY-based materials by encapsulating in micellar nanoparticles with Hexa BODIPY cyclophosphazene (HBCP) and DSPE-PEG2000 polymer. HBCP NPs also have a property of selectively accumulating in tumors with enhanced permeability and retention effect due to their bulky nano-size molecular structure. We checked the tumor targeting and retention time of HBCP NPs by monitoring them with fluorescence imaging. In addition, the high heat conversion efficiency of HBCP NPs enables photoacoustic imaging and Photothermal therapy. We also conducted whole body scanning of tail-vein injected tumor-bearing mice with acoustic resolution photoacoustic microscopy system to provide tumor accumulation information of HBCP NP with vascular structure. The result suggests that HBCP NP has a potential to be used as a material for image guided phototherapy.

AB - Photoacoustic imaging has begun to be widely used to observe drug delivery and accumulation in the body. Theranostic, which includes both diagnosis and therapy, is an attractive approach for treating cancer. In this study, we synthesized nanomaterials and verified the theranostic effect through fluorescence and photoacoustic imaging. Selectively transporting a drug to the tumor site is essential to increase the therapeutic effect while reducing side effects. BODIPY has the advantages of being able to change its structure more easily, good photostability, good biocompatibility and high absorption coefficient than cyanine or porphyrin dyes, however they are limited to in vivo experiment due to their poor water solubility. We overcome the limitations of BODIPY-based materials by encapsulating in micellar nanoparticles with Hexa BODIPY cyclophosphazene (HBCP) and DSPE-PEG2000 polymer. HBCP NPs also have a property of selectively accumulating in tumors with enhanced permeability and retention effect due to their bulky nano-size molecular structure. We checked the tumor targeting and retention time of HBCP NPs by monitoring them with fluorescence imaging. In addition, the high heat conversion efficiency of HBCP NPs enables photoacoustic imaging and Photothermal therapy. We also conducted whole body scanning of tail-vein injected tumor-bearing mice with acoustic resolution photoacoustic microscopy system to provide tumor accumulation information of HBCP NP with vascular structure. The result suggests that HBCP NP has a potential to be used as a material for image guided phototherapy.

KW - drug delivery

KW - Photoacoustic

KW - photoacoustic microscopy

KW - tumor-targeting drug

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U2 - 10.1117/12.2648142

DO - 10.1117/12.2648142

M3 - Conference contribution

AN - SCOPUS:85158944106

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

A2 - Wang, Lihong V.

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2023

Y2 - 29 January 2023 through 1 February 2023

ER -

Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging

Abstract

Publication series

Conference

Bibliographical note

Keywords

UN SDGs

Access to Document

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Cite this