Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a korean sponge monanchora sp.

Weihong Wang; Tae Gu Lee; Rahul S. Patil; Bora Mun; Inho Yang; Hiyoung Kim; Dongyup Hahn; Dong Hwan Won; Jihye Lee; Yehee Lee; Hyukjae Choi; Sang Jip Nam; Heonjoong Kang

doi:10.1021/np500760v

Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a korean sponge monanchora sp.

Weihong Wang
, Tae Gu Lee
, Rahul S. Patil
, Bora Mun
, Inho Yang
, Hiyoung Kim
, Dongyup Hahn
, Dong Hwan Won
, Jihye Lee
, Yehee Lee
, Hyukjae Choi
, Sang Jip Nam
, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.

Original language	English
Pages (from-to)	368-373
Number of pages	6
Journal	Journal of Natural Products
Volume	78
Issue number	3
DOIs	https://doi.org/10.1021/np500760v
State	Published - 27 Mar 2015

Bibliographical note

Publisher Copyright:
© 2014 The American Chemical Society and American Society of Pharmacognosy.

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title = "Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a korean sponge monanchora sp.",

abstract = "Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.",

author = "Weihong Wang and Lee, \{Tae Gu\} and Patil, \{Rahul S.\} and Bora Mun and Inho Yang and Hiyoung Kim and Dongyup Hahn and Won, \{Dong Hwan\} and Jihye Lee and Yehee Lee and Hyukjae Choi and Nam, \{Sang Jip\} and Heonjoong Kang",

note = "Publisher Copyright: {\textcopyright} 2014 The American Chemical Society and American Society of Pharmacognosy.",

year = "2015",

month = mar,

day = "27",

doi = "10.1021/np500760v",

language = "English",

volume = "78",

pages = "368--373",

journal = "Journal of Natural Products",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a korean sponge monanchora sp.

AU - Wang, Weihong

AU - Lee, Tae Gu

AU - Patil, Rahul S.

AU - Mun, Bora

AU - Yang, Inho

AU - Kim, Hiyoung

AU - Hahn, Dongyup

AU - Won, Dong Hwan

AU - Lee, Jihye

AU - Lee, Yehee

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Kang, Heonjoong

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.

AB - Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.

UR - https://www.scopus.com/pages/publications/84925961877

U2 - 10.1021/np500760v

DO - 10.1021/np500760v

M3 - Article

C2 - 25455409

AN - SCOPUS:84925961877

SN - 0163-3864

VL - 78

SP - 368

EP - 373

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a korean sponge monanchora sp.

Abstract

Bibliographical note

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