Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a korean sponge monanchora sp.

Weihong Wang, Tae Gu Lee, Rahul S. Patil, Bora Mun, Inho Yang, Hiyoung Kim, Dongyup Hahn, Dong Hwan Won, Jihye Lee, Yehee Lee, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

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22 Scopus citations

Abstract

Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalJournal of Natural Products
Volume78
Issue number3
DOIs
StatePublished - 27 Mar 2015

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