TY - JOUR
T1 - Molecular neuroimaging in posttraumatic stress disorder
AU - Im, Jooyeon Jamie
AU - Namgung, Eun
AU - Choi, Yejee
AU - Kim, Jung Yoon
AU - Rhie, Sandy Jeong
AU - Yoon, Sujung
N1 - Funding Information:
This research was supported by grants from the National Research Foundation of Korea (2015M3C7A1028373) and the Institute for Information & Communications Technology Promotion (B0132-15-1001) funded by the Ministry of Science, ICT & Future Planning (MSIP) of Korea.
Publisher Copyright:
© Experimental Neurobiology 2017.
PY - 2016
Y1 - 2016
N2 - Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS). Although there were some inconsistences in the findings, patients with PTSD showed altered cerebral metabolism and perfusion, receptor bindings, and metabolite profiles in the limbic regions, medial prefrontal cortex, and temporal cortex. Studies that have investigated brain correlates of treatment response are also reviewed. Lastly, the limitations of the molecular neuroimaging studies and potential future research directions are discussed.
AB - Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS). Although there were some inconsistences in the findings, patients with PTSD showed altered cerebral metabolism and perfusion, receptor bindings, and metabolite profiles in the limbic regions, medial prefrontal cortex, and temporal cortex. Studies that have investigated brain correlates of treatment response are also reviewed. Lastly, the limitations of the molecular neuroimaging studies and potential future research directions are discussed.
KW - Magnetic resonance spectroscopy (MRS)
KW - Molecular neuroimaging
KW - Positron emission tomography (PET)
KW - Posttraumatic stress disorder (PTSD)
KW - Single photon emission computed tomography (SPECT)
UR - http://www.scopus.com/inward/record.url?scp=85010192518&partnerID=8YFLogxK
U2 - 10.5607/en.2016.25.6.277
DO - 10.5607/en.2016.25.6.277
M3 - Article
AN - SCOPUS:85010192518
SN - 1226-2560
VL - 25
SP - 277
EP - 295
JO - Experimental Neurobiology
JF - Experimental Neurobiology
IS - 6
ER -