Molecular captain: A light-sensitive linker molecule in poly(ethylene glycol)-poly(L -alanine)-poly(ethylene glycol) triblock copolymer directs molecular nano-assembly, conformation, and sol-gel transition

So Young Jeong; Hyo Jung Moon; Min Hee Park; Min Kyung Joo; Byeongmoon Jeong

doi:10.1002/pola.26104

Molecular captain: A light-sensitive linker molecule in poly(ethylene glycol)-poly(L -alanine)-poly(ethylene glycol) triblock copolymer directs molecular nano-assembly, conformation, and sol-gel transition

So Young Jeong, Hyo Jung Moon, Min Hee Park, Min Kyung Joo, Byeongmoon Jeong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We report a poly(ethylene glycol)-poly(L-alanine)-azobenzene-poly(L- alanine)-poly(ethylene glycol) (PEG-PA-Z-PA-PEG) as a temperature and light sensitive polymer. The poly(ethylene glycol)-poly(L-alanine) diblock copolymers with a flexible-rigid block structure were coupled by an azobenzene group that undergoes a reversible configurational change between "trans" and "cis" upon exposure to UV and vis light. The single azobenzene molecule embedded in the middle of a block copolymer with a flexible (shell)-rigid (core) structure significantly affected molecular assembly, micelle size, polypeptide secondary structure, and sol-to-gel transition temperature of the polymer aqueous solution, depending on its exposure to UV or vis light.

Original language	English
Pages (from-to)	3184-3191
Number of pages	8
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	50
Issue number	15
DOIs	https://doi.org/10.1002/pola.26104
State	Published - 1 Aug 2012

Keywords

biomaterials
block copolymers
gels
micelles
self-assembly
stimuli-sensitive polymers

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Jeong, S. Y., Moon, H. J., Park, M. H., Joo, M. K., & Jeong, B. (2012). Molecular captain: A light-sensitive linker molecule in poly(ethylene glycol)-poly(L -alanine)-poly(ethylene glycol) triblock copolymer directs molecular nano-assembly, conformation, and sol-gel transition. Journal of Polymer Science, Part A: Polymer Chemistry, 50(15), 3184-3191. https://doi.org/10.1002/pola.26104

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abstract = "We report a poly(ethylene glycol)-poly(L-alanine)-azobenzene-poly(L- alanine)-poly(ethylene glycol) (PEG-PA-Z-PA-PEG) as a temperature and light sensitive polymer. The poly(ethylene glycol)-poly(L-alanine) diblock copolymers with a flexible-rigid block structure were coupled by an azobenzene group that undergoes a reversible configurational change between {"}trans{"} and {"}cis{"} upon exposure to UV and vis light. The single azobenzene molecule embedded in the middle of a block copolymer with a flexible (shell)-rigid (core) structure significantly affected molecular assembly, micelle size, polypeptide secondary structure, and sol-to-gel transition temperature of the polymer aqueous solution, depending on its exposure to UV or vis light.",

keywords = "biomaterials, block copolymers, gels, micelles, self-assembly, stimuli-sensitive polymers",

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Jeong, SY, Moon, HJ, Park, MH, Joo, MK & Jeong, B 2012, 'Molecular captain: A light-sensitive linker molecule in poly(ethylene glycol)-poly(L -alanine)-poly(ethylene glycol) triblock copolymer directs molecular nano-assembly, conformation, and sol-gel transition', Journal of Polymer Science, Part A: Polymer Chemistry, vol. 50, no. 15, pp. 3184-3191. https://doi.org/10.1002/pola.26104

Molecular captain: A light-sensitive linker molecule in poly(ethylene glycol)-poly(L -alanine)-poly(ethylene glycol) triblock copolymer directs molecular nano-assembly, conformation, and sol-gel transition. / Jeong, So Young; Moon, Hyo Jung; Park, Min Hee et al.
In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 50, No. 15, 01.08.2012, p. 3184-3191.

Research output: Contribution to journal › Article › peer-review

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