Molded porous poly (L-lactide) membranes for guided bone regeneration with enhanced effects by controlled growth factor release

Seung Jin Lee, Yoon Jeong Park, Si Nae Park, Yong Moo Lee, Yang Jo Seol, Young Ku, Chong Pyoung Chung

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


The aim of this study was to develop platelet-derived growth factor (PDGF-BB) loaded moldable porous poly (L-lactide) (PLLA)-tricalcium phosphate (TCP) membranes for guided bone regeneration (GBR) therapy. The membranes were designed to fit various types of bone defect sites. PDGF-BB-dissolved PLLA-TCP in methylene chloride-ethyl acetate solution was cast on a dome shaped metallic mold to fabricate a model membrane. The release rate of PDGF-BB, the osteoblast attachment test, and guided bone regeneration potential were evaluated with PDGF-BB-loaded PLLA-TCP membranes. Regular pores were generated throughout the membrane mainly due to phase inversion of PLLA-methylene chloride-ethyl acetate solution. A therapeutic amount of PDGF-BB was released from the membrane. The release rate could be controlled by varying the initial loading content of PDGF-BB. A significant amount of cells attached onto the PDGF-BB-loaded membrane rather than onto the unloaded membrane. Dome shaped bone formation was achieved in rabbit calvaria at 4 weeks. This indicated that restoration of bone defects to the bone's original shape can be made possible by using molded membranes, which guide bone regeneration along with providing sufficient spaces. Bone forming efficiency was increased remarkably due to PDGF-BB release from PLLA-TCP membranes. These results suggested that the PDGF-BB releasing molded PLLA-TCP membrane may potentially improve GBR efficiency in various types of bone defects.

Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalJournal of Biomedical Materials Research
Issue number3
StatePublished - 5 Jun 2001


  • Controlled release
  • Guided bone regeneration
  • Molded membrane
  • Platelet-derived growth factor-BB
  • Poly (L-lactide)-tricalcium phosphate (TCP) membrane


Dive into the research topics of 'Molded porous poly (L-lactide) membranes for guided bone regeneration with enhanced effects by controlled growth factor release'. Together they form a unique fingerprint.

Cite this