Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting candida albicans isocitrate lyase

Munhyung Bae, Heegyu Kim, Kyuho Moon, Sang Jip Nam, Jongheon Shin, Ki Bong Oh, Dong Chan Oh

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Mohangamides A and B (1-2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectroscopic analysis. The absolute configurations of the mohangamides were determined by chemical derivatizations, followed by chromatographic and spectroscopic analyses. Mohangamide A displayed strong inhibitory activity against Candida albicans isocitrate lyase.

Original languageEnglish
Pages (from-to)712-715
Number of pages4
JournalOrganic Letters
Volume17
Issue number3
DOIs
StatePublished - 6 Feb 2015

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