Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting candida albicans isocitrate lyase

Munhyung Bae; Heegyu Kim; Kyuho Moon; Sang Jip Nam; Jongheon Shin; Ki Bong Oh; Dong Chan Oh

doi:10.1021/ol5037248

Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting candida albicans isocitrate lyase

Munhyung Bae, Heegyu Kim, Kyuho Moon, Sang Jip Nam, Jongheon Shin, Ki Bong Oh, Dong Chan Oh

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Mohangamides A and B (1-2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectroscopic analysis. The absolute configurations of the mohangamides were determined by chemical derivatizations, followed by chromatographic and spectroscopic analyses. Mohangamide A displayed strong inhibitory activity against Candida albicans isocitrate lyase.

Original language	English
Pages (from-to)	712-715
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	3
DOIs	https://doi.org/10.1021/ol5037248
State	Published - 6 Feb 2015

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Publisher Copyright:
© 2015 American Chemical Society.

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abstract = "Mohangamides A and B (1-2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectroscopic analysis. The absolute configurations of the mohangamides were determined by chemical derivatizations, followed by chromatographic and spectroscopic analyses. Mohangamide A displayed strong inhibitory activity against Candida albicans isocitrate lyase.",

author = "Munhyung Bae and Heegyu Kim and Kyuho Moon and Nam, {Sang Jip} and Jongheon Shin and Oh, {Ki Bong} and Oh, {Dong Chan}",

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AU - Bae, Munhyung

AU - Kim, Heegyu

AU - Moon, Kyuho

AU - Nam, Sang Jip

AU - Shin, Jongheon

AU - Oh, Ki Bong

AU - Oh, Dong Chan

PY - 2015/2/6

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AB - Mohangamides A and B (1-2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectroscopic analysis. The absolute configurations of the mohangamides were determined by chemical derivatizations, followed by chromatographic and spectroscopic analyses. Mohangamide A displayed strong inhibitory activity against Candida albicans isocitrate lyase.

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JF - Organic Letters

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ER -

Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting candida albicans isocitrate lyase

Abstract

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