Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)

Na Kyung Lee, Soo Young Lee

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-κB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of Biochemistry and Molecular Biology
Volume35
Issue number1
DOIs
StatePublished - 31 Jan 2002

Keywords

  • Apoptosis
  • Cell survival
  • TNF receptor superfamily
  • TRAF

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