Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)

Na Kyung Lee, Soo Young Lee

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-κB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of Biochemistry and Molecular Biology
Volume35
Issue number1
DOIs
StatePublished - 31 Jan 2002

Bibliographical note

Funding Information:
Andrew Conway Morris is supported by a Clinical Research Career Development Fellowship from the Wellcome Trust (WT 2055214/Z/16/Z). Niccolò Buetti is currently receiving a Post.doc Mobility grant from the Swiss National Science Foundation (grant number: P400PM_183865) and a grant from the Bangerter-Rhyner Foundation.

Funding Information:
Dr. Tabah has nothing to disclose, Dr. Ramanan has nothing to disclose, Prof. Laupland has nothing to disclose, Dr. Buetti has nothing to disclose, Dr. Cortegiani has nothing to disclose, Mr. Mellinghoff has nothing to disclose, Dr. Conway Morris reports grants from Wellcome Trust, during the conduct of the study; Dr. Camporota has nothing to disclose, Dr. Zappella has nothing to disclose, Dr. Vidal has nothing to disclose, Dr. Elhadi has nothing to disclose, Dr. Povoa reports personal fess from Orion, personal fees from Pfizer and personal fees from Technofage, Dr. Amrein reports grants, personal fees and other from Fresenius Kabi, personal fees from Vifor Pharma, personal fees from Shire now part of Takeda, outside the submitted work, Dr. Derde reports grants from European Union, grants from ZonMw, outside the submitted work, Guy Francoishas nothing to disclose, Dr. Bassetti reports grants and personal fees from Pfizer, grants and personal fees from MSD, grants and personal fees from Menarini, grants and personal fees from Angelini, personal fees from Astellas, personal fees from Nabriva, grants and personal fees from Paratek, personal fees from Gilead, personal fees from Basilea, personal fees from Cidara, personal fees from Molteni, outside the submitted work; Dr. Ssi Yan Kai has nothing to disclose, Dr. De Waelereports grants from Research Foundation Flanders, during the conduct of the study; other from Bayer, other from Pfizer, other from MSD, other from Grifols, other from Accelerate, outside the submitted work;.

Keywords

  • Apoptosis
  • Cell survival
  • TNF receptor superfamily
  • TRAF

Fingerprint

Dive into the research topics of 'Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)'. Together they form a unique fingerprint.

Cite this