Modified smear method for screening potential inhibitors of platelet aggregation from plant sources

Hye Sook Yun-Choi, Sun Ok Kim, Jae Hoon Kim, Jong Ran Lee

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The smear method developed by Velaskar and Chitre was modified to allow the massive screening of plant extracts and/or fractions for platelet antiaggregating activity. Aspirin and papaverine, known inhibitors of platelet aggregation, were tested by the modified method and showed comparable results with previously reported data. Fifty-four fractions prepared from eighteen plant species were screened for their inhibitory effects on adenosine 5'-diphosphate, arachidonic acid, or collagen-induced rat platelet aggregation. The results suggest that plants could be a potential source of inhibitors of platelet aggregation.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalJournal of Natural Products
Volume48
Issue number3
DOIs
StatePublished - May 1985

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