Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives

Takeshi Iwatsubo; Reisa A. Sperling; Alicia Algeciras-Schimnich; Hidenori Arai; Anna M. Barron; Tammie L.S. Benzinger; Maria C. Carrillo; Christopher Chen; Seong Hye Choi; Igor C. Fontana; Jonathan Graff-Radford; Joshua D. Grill; Judith Heidebrink; Chaur Jong Hu; Ryoko Ihara; Takeshi Ikeuchi; Atsushi Iwata; Fanny C.F. Ip; Fasihah Irfani Fitri; Clifford R. Jack; Jee Hyang Jeong; Jianping Jia; Nagaendran Kandiah; Sang Yun Kim; Hisatomo Kowa; Renaud La Joie; Yoshiki Niimi; Ryoji Noritake; Ozioma C. Okonkwo; Sebastian Palmqvist; Michael S. Rafii; Rema Raman; Yong Shen; Tanya Simuni; Heather M. Snyder; Orapitchaya Sriwannopas; Luke E. Stoeckel; Wiesje M. van der Flier; Huali Wang; Donna M. Wilcock; Henrik Zetterberg; Jin Zhou; Simin Mahinrad; Claire E. Sexton

doi:10.1002/alz.70536

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives

Takeshi Iwatsubo
, Reisa A. Sperling
, Alicia Algeciras-Schimnich
, Hidenori Arai
, Anna M. Barron
, Tammie L.S. Benzinger
, Maria C. Carrillo
, Christopher Chen
, Seong Hye Choi
, Igor C. Fontana
, Jonathan Graff-Radford
, Joshua D. Grill
, Judith Heidebrink
, Chaur Jong Hu
, Ryoko Ihara
, Takeshi Ikeuchi
, Atsushi Iwata
, Fanny C.F. Ip
, Fasihah Irfani Fitri
, Clifford R. Jack

Jee Hyang Jeong, Jianping Jia, Nagaendran Kandiah, Sang Yun Kim, Hisatomo Kowa, Renaud La Joie, Yoshiki Niimi, Ryoji Noritake, Ozioma C. Okonkwo, Sebastian Palmqvist, Michael S. Rafii, Rema Raman, Yong Shen, Tanya Simuni, Heather M. Snyder, Orapitchaya Sriwannopas, Luke E. Stoeckel, Wiesje M. van der Flier, Huali Wang, Donna M. Wilcock, Henrik Zetterberg, Jin Zhou, Simin Mahinrad, Claire E. Sexton

Department of Neurology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.

Original language	English
Article number	e70536
Journal	Alzheimer's and Dementia
Volume	21
Issue number	8
DOIs	https://doi.org/10.1002/alz.70536
State	Published - Aug 2025

Bibliographical note

Publisher Copyright:
© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer's disease
Asia
biomarker
dementia
diagnosis

Access to Document

10.1002/alz.70536

Cite this

Iwatsubo, T., Sperling, R. A., Algeciras-Schimnich, A., Arai, H., Barron, A. M., Benzinger, T. L. S., Carrillo, M. C., Chen, C., Choi, S. H., Fontana, I. C., Graff-Radford, J., Grill, J. D., Heidebrink, J., Hu, C. J., Ihara, R., Ikeuchi, T., Iwata, A., Ip, F. C. F., Fitri, F. I., ... Sexton, C. E. (2025). Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives. Alzheimer's and Dementia, 21(8), Article e70536. https://doi.org/10.1002/alz.70536

@article{6b0235934c614d3ab6367847157e51af,

title = "Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives",

abstract = "The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions{\textemdash}encompassing pharmacological and non-pharmacological strategies{\textemdash}and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.",

keywords = "Alzheimer's disease, Asia, biomarker, dementia, diagnosis",

author = "Takeshi Iwatsubo and Sperling, \{Reisa A.\} and Alicia Algeciras-Schimnich and Hidenori Arai and Barron, \{Anna M.\} and Benzinger, \{Tammie L.S.\} and Carrillo, \{Maria C.\} and Christopher Chen and Choi, \{Seong Hye\} and Fontana, \{Igor C.\} and Jonathan Graff-Radford and Grill, \{Joshua D.\} and Judith Heidebrink and Hu, \{Chaur Jong\} and Ryoko Ihara and Takeshi Ikeuchi and Atsushi Iwata and Ip, \{Fanny C.F.\} and Fitri, \{Fasihah Irfani\} and Jack, \{Clifford R.\} and Jeong, \{Jee Hyang\} and Jianping Jia and Nagaendran Kandiah and Kim, \{Sang Yun\} and Hisatomo Kowa and \{La Joie\}, Renaud and Yoshiki Niimi and Ryoji Noritake and Okonkwo, \{Ozioma C.\} and Sebastian Palmqvist and Rafii, \{Michael S.\} and Rema Raman and Yong Shen and Tanya Simuni and Snyder, \{Heather M.\} and Orapitchaya Sriwannopas and Stoeckel, \{Luke E.\} and \{van der Flier\}, \{Wiesje M.\} and Huali Wang and Wilcock, \{Donna M.\} and Henrik Zetterberg and Jin Zhou and Simin Mahinrad and Sexton, \{Claire E.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Alzheimer's \& Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2025",

month = aug,

doi = "10.1002/alz.70536",

language = "English",

volume = "21",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "8",

}

Iwatsubo, T, Sperling, RA, Algeciras-Schimnich, A, Arai, H, Barron, AM, Benzinger, TLS, Carrillo, MC, Chen, C, Choi, SH, Fontana, IC, Graff-Radford, J, Grill, JD, Heidebrink, J, Hu, CJ, Ihara, R, Ikeuchi, T, Iwata, A, Ip, FCF, Fitri, FI, Jack, CR, Jeong, JH, Jia, J, Kandiah, N, Kim, SY, Kowa, H, La Joie, R, Niimi, Y, Noritake, R, Okonkwo, OC, Palmqvist, S, Rafii, MS, Raman, R, Shen, Y, Simuni, T, Snyder, HM, Sriwannopas, O, Stoeckel, LE, van der Flier, WM, Wang, H, Wilcock, DM, Zetterberg, H, Zhou, J, Mahinrad, S & Sexton, CE 2025, 'Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives', Alzheimer's and Dementia, vol. 21, no. 8, e70536. https://doi.org/10.1002/alz.70536

TY - JOUR

T1 - Modernizing diagnosis of Alzheimer's disease

T2 - A review of global trends and Asia-specific perspectives

AU - Iwatsubo, Takeshi

AU - Sperling, Reisa A.

AU - Algeciras-Schimnich, Alicia

AU - Arai, Hidenori

AU - Barron, Anna M.

AU - Benzinger, Tammie L.S.

AU - Carrillo, Maria C.

AU - Chen, Christopher

AU - Choi, Seong Hye

AU - Fontana, Igor C.

AU - Graff-Radford, Jonathan

AU - Grill, Joshua D.

AU - Heidebrink, Judith

AU - Hu, Chaur Jong

AU - Ihara, Ryoko

AU - Ikeuchi, Takeshi

AU - Iwata, Atsushi

AU - Ip, Fanny C.F.

AU - Fitri, Fasihah Irfani

AU - Jack, Clifford R.

AU - Jeong, Jee Hyang

AU - Jia, Jianping

AU - Kandiah, Nagaendran

AU - Kim, Sang Yun

AU - Kowa, Hisatomo

AU - La Joie, Renaud

AU - Niimi, Yoshiki

AU - Noritake, Ryoji

AU - Okonkwo, Ozioma C.

AU - Palmqvist, Sebastian

AU - Rafii, Michael S.

AU - Raman, Rema

AU - Shen, Yong

AU - Simuni, Tanya

AU - Snyder, Heather M.

AU - Sriwannopas, Orapitchaya

AU - Stoeckel, Luke E.

AU - van der Flier, Wiesje M.

AU - Wang, Huali

AU - Wilcock, Donna M.

AU - Zetterberg, Henrik

AU - Zhou, Jin

AU - Mahinrad, Simin

AU - Sexton, Claire E.

PY - 2025/8

Y1 - 2025/8

N2 - The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.

AB - The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.

KW - Alzheimer's disease

KW - Asia

KW - biomarker

KW - dementia

KW - diagnosis

UR - https://www.scopus.com/pages/publications/105012409918

U2 - 10.1002/alz.70536

DO - 10.1002/alz.70536

M3 - Review article

C2 - 40760693

AN - SCOPUS:105012409918

SN - 1552-5260

VL - 21

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 8

M1 - e70536

ER -

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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Cite this