Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer

Dokyoon Kim, Jung Rok Lee, Eric Shen, Shan X. Wang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We present a resistive network model, protein assay data, and outlook of the giant magnetoresistive (GMR) spin-valve magneto-nanosensor platform ideal for multiplexed detection of protein biomarkers in solutions. The magneto-nanosensors are designed to have optimal performance considering several factors such as sensor dimension, shape anisotropy, and magnetic nanoparticle tags. The resistive network model indicates that thinner spin-valve sensors with narrower width lead to higher signals from magnetic nanoparticle tags. Standard curves and real-time measurements showed a sensitivity of ~10 pM for phosphorylated-structural maintenance of chromosome 1 (phosphor-SMC1), ~53 fM for granulocyte colony stimulation factor (GCSF), and ~460 fM for interleukin-6 (IL6), which are among the representative biomarkers for radiation exposure and cancer.

Original languageEnglish
Pages (from-to)665-671
Number of pages7
JournalBiomedical Microdevices
Volume15
Issue number4
DOIs
StatePublished - Aug 2013

Keywords

  • Cancer biomarker
  • Immunoassay
  • Magnetic nanoparticles
  • Nanosensor
  • Radiation biomarker

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