Abstract
We present a resistive network model, protein assay data, and outlook of the giant magnetoresistive (GMR) spin-valve magneto-nanosensor platform ideal for multiplexed detection of protein biomarkers in solutions. The magneto-nanosensors are designed to have optimal performance considering several factors such as sensor dimension, shape anisotropy, and magnetic nanoparticle tags. The resistive network model indicates that thinner spin-valve sensors with narrower width lead to higher signals from magnetic nanoparticle tags. Standard curves and real-time measurements showed a sensitivity of ~10 pM for phosphorylated-structural maintenance of chromosome 1 (phosphor-SMC1), ~53 fM for granulocyte colony stimulation factor (GCSF), and ~460 fM for interleukin-6 (IL6), which are among the representative biomarkers for radiation exposure and cancer.
Original language | English |
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Pages (from-to) | 665-671 |
Number of pages | 7 |
Journal | Biomedical Microdevices |
Volume | 15 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2013 |
Keywords
- Cancer biomarker
- Immunoassay
- Magnetic nanoparticles
- Nanosensor
- Radiation biomarker