Mixed ligand octahedral Zn(II) complex of N^N^O donor tridentate Schiff base ligand and N^N donor bidentate bipyridine ligand: Synthesis, characterization, biological activity and cytotoxicity

Thamilarasan Vijayan, Mani Pugazhenthi, Azam Nasirian, Jinheung Kim, Gopinath Kasi, Arumugam Jayamani

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Tridentate NNO donor Schiff base ligand and its mixed ligand zinc(II) complex were synthesized stoichiometrically and characterized by electronic, infrared, mass spectral techniques and elemental analysis. To understand the DNA binding ability, the complex was investigated by various analytical and spectroscopic techniques in presence of calf thymus DNA (CT-DNA). The binding studies showed that the zinc complex interacts with DNA by groove binding mode with intrinsic binding strength of 2.11 × 105 M−1 and with bovine serum albumin the complex showed dynamic quenching attributed for changes in the secondary structure of BSA with efficient interaction. The MCF-7 cell line studies of the zinc(II) complex with 90.8 μM IC50 value revealed that the complex is effective for the breast cancer cell line and has a potential as anticancer drug. Furthermore, the tridentate ligand and its mixed ligand zinc complex were screened for antibacterial and antifungal activities, which showed better antimicrobial activity for complex.

Original languageEnglish
Pages (from-to)1284-1292
Number of pages9
JournalBulletin of the Korean Chemical Society
Volume43
Issue number11
DOIs
StatePublished - Nov 2022

Bibliographical note

Funding Information:
The publication cost of this paper was supported by the Korean Chemical Society.

Publisher Copyright:
© 2022 Korean Chemical Society, Seoul & Wiley-VCH GmbH.

Keywords

  • antimicrobial activities
  • biomolecular interaction
  • cytotoxicity studies
  • mixed ligand Zn(II) complex
  • tridentate NNO Schiff base

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