Misassigned natural products and their revised structures

Hye Dong Yoo; Sang Jip Nam; Young Won Chin; Min Sun Kim

doi:10.1007/s12272-015-0649-9

Misassigned natural products and their revised structures

Hye Dong Yoo, Sang Jip Nam, Young Won Chin, Min Sun Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.

Original language	English
Pages (from-to)	143-153
Number of pages	11
Journal	Archives of Pharmacal Research
Volume	39
Issue number	2
DOIs	https://doi.org/10.1007/s12272-015-0649-9
State	Published - 1 Feb 2016

Bibliographical note

Publisher Copyright:
© 2015 The Pharmaceutical Society of Korea.

Keywords

Drug development
NMR
Natural product
PK/PD
Structure determination
Structure-activity relationship

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10.1007/s12272-015-0649-9

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abstract = "Natural products are a major pipeline for drug development and are responsible for more than 50 \% of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.",

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AU - Yoo, Hye Dong

AU - Nam, Sang Jip

AU - Chin, Young Won

AU - Kim, Min Sun

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N2 - Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.

AB - Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.

KW - Drug development

KW - NMR

KW - Natural product

KW - PK/PD

KW - Structure determination

KW - Structure-activity relationship

UR - https://www.scopus.com/pages/publications/84958117108

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Misassigned natural products and their revised structures

Abstract

Bibliographical note

Keywords

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