Misassigned natural products and their revised structures

Hye Dong Yoo, Sang Jip Nam, Young Won Chin, Min Sun Kim

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.

Original languageEnglish
Pages (from-to)143-153
Number of pages11
JournalArchives of Pharmacal Research
Volume39
Issue number2
DOIs
StatePublished - 1 Feb 2016

Keywords

  • Drug development
  • Natural product
  • NMR
  • PK/PD
  • Structure determination
  • Structure-activity relationship

Fingerprint

Dive into the research topics of 'Misassigned natural products and their revised structures'. Together they form a unique fingerprint.

Cite this