Abstract
Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.
Original language | English |
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Pages (from-to) | 143-153 |
Number of pages | 11 |
Journal | Archives of Pharmacal Research |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - 1 Feb 2016 |
Bibliographical note
Publisher Copyright:© 2015 The Pharmaceutical Society of Korea.
Keywords
- Drug development
- NMR
- Natural product
- PK/PD
- Structure determination
- Structure-activity relationship