miR-93/miR-106b/miR-375-CIC-CRABP1: A novel regulatory axis in prostate cancer progression

Nahyun Choi; Jongmin Park; Jeon Soo Lee; Jeehyun Yoe; Guk Yeol Park; Eunjeong Kim; Hyeongrin Jeon; Yong Mee Cho; Tae Young Roh; Yoontae Lee

doi:10.18632/oncotarget.4372

miR-93/miR-106b/miR-375-CIC-CRABP1: A novel regulatory axis in prostate cancer progression

Nahyun Choi, Jongmin Park, Jeon Soo Lee, Jeehyun Yoe, Guk Yeol Park, Eunjeong Kim, Hyeongrin Jeon, Yong Mee Cho, Tae Young Roh, Yoontae Lee

Department of Life Science

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type-1 (SCA1) neurodegenerative disease and some types of cancer; however, the role of CIC in prostate cancer remains unknown. Here we show that CIC suppresses prostate cancer progression. CIC expression was markedly decreased in human prostatic carcinoma. CIC overexpression suppressed prostate cancer cell proliferation, invasion, and migration, whereas CIC RNAi exerted opposite effects. We found that knock-down of CIC derepresses expression of ETV5 and CRABP1 in LNCaP and PC-3 cells, respectively, thereby promoting cell proliferation and invasion. We also discovered that miR-93, miR-106b, and miR-375, which are known to be frequently overexpressed in prostate cancer patients, cooperatively down-regulate CIC levels to promote cancer progression. Altogether, we suggest miR-93/miR-106b/miR-375- CIC-CRABP1 as a novel key regulatory axis in prostate cancer progression.

Original language	English
Pages (from-to)	23533-23547
Number of pages	15
Journal	Oncotarget
Volume	6
Issue number	27
DOIs	https://doi.org/10.18632/oncotarget.4372
State	Published - 2015

Keywords

CRABP1
Capicua
ETV5
MicroRNA
Prostate cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "miR-93/miR-106b/miR-375-CIC-CRABP1: A novel regulatory axis in prostate cancer progression",

abstract = "Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type-1 (SCA1) neurodegenerative disease and some types of cancer; however, the role of CIC in prostate cancer remains unknown. Here we show that CIC suppresses prostate cancer progression. CIC expression was markedly decreased in human prostatic carcinoma. CIC overexpression suppressed prostate cancer cell proliferation, invasion, and migration, whereas CIC RNAi exerted opposite effects. We found that knock-down of CIC derepresses expression of ETV5 and CRABP1 in LNCaP and PC-3 cells, respectively, thereby promoting cell proliferation and invasion. We also discovered that miR-93, miR-106b, and miR-375, which are known to be frequently overexpressed in prostate cancer patients, cooperatively down-regulate CIC levels to promote cancer progression. Altogether, we suggest miR-93/miR-106b/miR-375- CIC-CRABP1 as a novel key regulatory axis in prostate cancer progression.",

keywords = "CRABP1, Capicua, ETV5, MicroRNA, Prostate cancer",

author = "Nahyun Choi and Jongmin Park and Lee, {Jeon Soo} and Jeehyun Yoe and Park, {Guk Yeol} and Eunjeong Kim and Hyeongrin Jeon and Cho, {Yong Mee} and Roh, {Tae Young} and Yoontae Lee",

year = "2015",

doi = "10.18632/oncotarget.4372",

language = "English",

volume = "6",

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TY - JOUR

T1 - miR-93/miR-106b/miR-375-CIC-CRABP1

T2 - A novel regulatory axis in prostate cancer progression

AU - Choi, Nahyun

AU - Park, Jongmin

AU - Lee, Jeon Soo

AU - Yoe, Jeehyun

AU - Park, Guk Yeol

AU - Kim, Eunjeong

AU - Jeon, Hyeongrin

AU - Cho, Yong Mee

AU - Roh, Tae Young

AU - Lee, Yoontae

PY - 2015

Y1 - 2015

N2 - Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type-1 (SCA1) neurodegenerative disease and some types of cancer; however, the role of CIC in prostate cancer remains unknown. Here we show that CIC suppresses prostate cancer progression. CIC expression was markedly decreased in human prostatic carcinoma. CIC overexpression suppressed prostate cancer cell proliferation, invasion, and migration, whereas CIC RNAi exerted opposite effects. We found that knock-down of CIC derepresses expression of ETV5 and CRABP1 in LNCaP and PC-3 cells, respectively, thereby promoting cell proliferation and invasion. We also discovered that miR-93, miR-106b, and miR-375, which are known to be frequently overexpressed in prostate cancer patients, cooperatively down-regulate CIC levels to promote cancer progression. Altogether, we suggest miR-93/miR-106b/miR-375- CIC-CRABP1 as a novel key regulatory axis in prostate cancer progression.

AB - Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type-1 (SCA1) neurodegenerative disease and some types of cancer; however, the role of CIC in prostate cancer remains unknown. Here we show that CIC suppresses prostate cancer progression. CIC expression was markedly decreased in human prostatic carcinoma. CIC overexpression suppressed prostate cancer cell proliferation, invasion, and migration, whereas CIC RNAi exerted opposite effects. We found that knock-down of CIC derepresses expression of ETV5 and CRABP1 in LNCaP and PC-3 cells, respectively, thereby promoting cell proliferation and invasion. We also discovered that miR-93, miR-106b, and miR-375, which are known to be frequently overexpressed in prostate cancer patients, cooperatively down-regulate CIC levels to promote cancer progression. Altogether, we suggest miR-93/miR-106b/miR-375- CIC-CRABP1 as a novel key regulatory axis in prostate cancer progression.

KW - CRABP1

KW - Capicua

KW - ETV5

KW - MicroRNA

KW - Prostate cancer

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U2 - 10.18632/oncotarget.4372

DO - 10.18632/oncotarget.4372

M3 - Article

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AN - SCOPUS:84943409869

SN - 1949-2553

VL - 6

SP - 23533

EP - 23547

JO - Oncotarget

JF - Oncotarget

IS - 27

ER -

miR-93/miR-106b/miR-375-CIC-CRABP1: A novel regulatory axis in prostate cancer progression

Abstract

Keywords

UN SDGs

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