MicroRNA-769-3p Acts as a Prognostic Factor in Oral Squamous Cell Cancer by Modulating Stromal Genes

Heejin Lee, Sang Hoon Chun, Seo Yun Moon, Jung Sook Yoon, Hye Sung Won, Soon Auck Hong, Seo Ree Kim, Kwang Jae Cho, Keunsoo Kang, Sieun Lee, Young Ho Ahn, Ji Hyung Hong, Yoon Ho Ko

Research output: Contribution to journalArticlepeer-review


miR-769-3p expression is suppressed in the stromal subtype of head and neck squamous cell carcinoma (HNSCC); however, its role in stromal HNSCC has not been fully elucidated. To investigate the biological relevance of miR-769-3p in the stromal phenotype, we established oral squamous cell cancer (OSCC) cell lines, namely CAL27, HSC3, and YD8, overexpressing miR-769-3p. miR-769-3p expression was positively and negatively correlated with interferon-gamma-related genes and MYC target gene sets, respectively. miR-769-3p decreased OSCC cell migration and invasion as well as mesenchymal marker expression and increased epithelial marker expression. Moreover, miR-769-3p enhanced OSCC cell sensitivity to 5-fluorouracil. High miR-769-3p expression was associated with good prognosis of HNSCC patients. Collectively, these results suggest that miR-769-3p suppression enhances stromal gene expression and promotes the epithelial-to-mesenchymal transition. Therefore, miR-769-3p may be a potential biomarker of the miRNA phenotype in OSCC patients.

Original languageEnglish
Article number4373
Issue number18
StatePublished - Sep 2022


  • EMT
  • head and neck neoplasm
  • miR-769
  • stroma
  • tumor-suppressive


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