Microfluidic self-assembly of tumor spheroids for studies of anticancer drug actions and interactions

Liz Y. Wu; Dino Di Carlo; Luke P. Lee

Microfluidic self-assembly of tumor spheroids for studies of anticancer drug actions and interactions

Liz Y. Wu, Dino Di Carlo, Luke P. Lee

Department of Chemistry & Nanoscience

Research output: Contribution to conference › Paper › peer-review

Abstract

Multicellular tumor spheroids may provide a better model than monolayer culture of in vivo tumors for drug assays. We present a novel microfluidic method for self-assembly of tumor spheroids for these studies. Our device traps cancer cells hydrodynamically and spheroid formation is enhanced by maintaining compact groups of the trapped cells due to continuous perfusion. A large amount of tumor spheroids with a narrow size distribution can be formed in the device to provide a good platform for anticancer drug assays.

Original language	English
Pages	1011-1013
Number of pages	3
State	Published - 2006
Event	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 5 Nov 2006 → 9 Nov 2006

Conference

Conference	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
Country/Territory	Japan
City	Tokyo
Period	5/11/06 → 9/11/06

Keywords

Drug discovery
MCTS
Self-assembly of spheroids
Tumor spheroids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Microfluidic self-assembly of tumor spheroids for studies of anticancer drug actions and interactions",

abstract = "Multicellular tumor spheroids may provide a better model than monolayer culture of in vivo tumors for drug assays. We present a novel microfluidic method for self-assembly of tumor spheroids for these studies. Our device traps cancer cells hydrodynamically and spheroid formation is enhanced by maintaining compact groups of the trapped cells due to continuous perfusion. A large amount of tumor spheroids with a narrow size distribution can be formed in the device to provide a good platform for anticancer drug assays.",

keywords = "Drug discovery, MCTS, Self-assembly of spheroids, Tumor spheroids",

author = "Wu, {Liz Y.} and {Di Carlo}, Dino and Lee, {Luke P.}",

year = "2006",

language = "English",

pages = "1011--1013",

note = "10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 ; Conference date: 05-11-2006 Through 09-11-2006",

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TY - CONF

T1 - Microfluidic self-assembly of tumor spheroids for studies of anticancer drug actions and interactions

AU - Wu, Liz Y.

AU - Di Carlo, Dino

AU - Lee, Luke P.

PY - 2006

Y1 - 2006

N2 - Multicellular tumor spheroids may provide a better model than monolayer culture of in vivo tumors for drug assays. We present a novel microfluidic method for self-assembly of tumor spheroids for these studies. Our device traps cancer cells hydrodynamically and spheroid formation is enhanced by maintaining compact groups of the trapped cells due to continuous perfusion. A large amount of tumor spheroids with a narrow size distribution can be formed in the device to provide a good platform for anticancer drug assays.

AB - Multicellular tumor spheroids may provide a better model than monolayer culture of in vivo tumors for drug assays. We present a novel microfluidic method for self-assembly of tumor spheroids for these studies. Our device traps cancer cells hydrodynamically and spheroid formation is enhanced by maintaining compact groups of the trapped cells due to continuous perfusion. A large amount of tumor spheroids with a narrow size distribution can be formed in the device to provide a good platform for anticancer drug assays.

KW - Drug discovery

KW - MCTS

KW - Self-assembly of spheroids

KW - Tumor spheroids

UR - http://www.scopus.com/inward/record.url?scp=84902474785&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:84902474785

SP - 1011

EP - 1013

T2 - 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

Y2 - 5 November 2006 through 9 November 2006

ER -

Microfluidic self-assembly of tumor spheroids for studies of anticancer drug actions and interactions

Abstract

Conference

Keywords

UN SDGs

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Cite this