Microbial cell factories for the production of three-carbon backbone organic acids from agro-industrial wastes

Jina Son, Kei Anne Baritugo, Seo Hyun Lim, Hye Jin Lim, Seona Jeong, Ji Yeon Lee, Jong il Choi, Jeong Chan Joo, Jeong Geol Na, Si Jae Park

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

At present, mass production of basic and valuable commodities is dependent on linear petroleum-based industries, which ultimately makes the depletion of finite natural reserves and accumulation of non-biodegradable and hazardous wastes. Therefore, an ecofriendly and sustainable solution should be established for a circular economy where infinite resources, such as agro-industrial wastes, are fully utilized as substrates in the production of target value-added chemicals. Hereby, recent advances in metabolic engineering strategies and techniques used in the development of microbial cell factories for enhanced production of three-carbon platform chemicals such as lactic acid, propionic acid, and 3-hydroxypropionic acid are discussed. Further developments and future perspectives in the production of these organic acids from agro-industrial wastes from the dairy, sugar, and biodiesel industries are also highlighted to demonstrate the importance of waste-based biorefineries for organic acid production.

Original languageEnglish
Article number126797
JournalBioresource Technology
Volume349
DOIs
StatePublished - Apr 2022

Keywords

  • Agro-industrial wastes
  • Circular economy
  • Metabolic engineering
  • Microbial cell factory
  • Three-carbon platform chemicals

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