Abstract
Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.
| Original language | English |
|---|---|
| Pages (from-to) | 231-239 |
| Number of pages | 9 |
| Journal | Biomolecules and Therapeutics |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2024 |
Bibliographical note
Publisher Copyright:© 2024 The Korean Society of Applied Pharmacology.
Keywords
- Anti-ppig-mentary agent
- Cyclic adenosine monophosphate
- Melanoderm™
- Melanogenesis
- Methyl anthranilate
- Skin pigmentation
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