Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression

Heui Jin Park; Kyuri Kim; Eun Young Lee; Prima F. Hillman; Sang Jip Nam; Kyung Min Lim

doi:10.4062/biomolther.2023.103

Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression

Heui Jin Park, Kyuri Kim, Eun Young Lee, Prima F. Hillman, Sang Jip Nam, Kyung Min Lim

Research output: Contribution to journal › Article › peer-review

Abstract

Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.

Original language	English
Pages (from-to)	231-239
Number of pages	9
Journal	Biomolecules and Therapeutics
Volume	32
Issue number	2
DOIs	https://doi.org/10.4062/biomolther.2023.103
State	Published - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Korean Society of Applied Pharmacology.

Keywords

Anti-ppig-mentary agent
Cyclic adenosine monophosphate
Melanoderm™
Melanogenesis
Methyl anthranilate
Skin pigmentation

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10.4062/biomolther.2023.103

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title = "Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression",

abstract = "Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm{\texttrademark}. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.",

keywords = "Anti-ppig-mentary agent, Cyclic adenosine monophosphate, Melanoderm{\texttrademark}, Melanogenesis, Methyl anthranilate, Skin pigmentation",

author = "Park, {Heui Jin} and Kyuri Kim and Lee, {Eun Young} and Hillman, {Prima F.} and Nam, {Sang Jip} and Lim, {Kyung Min}",

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year = "2024",

doi = "10.4062/biomolther.2023.103",

language = "English",

volume = "32",

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T1 - Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression

AU - Park, Heui Jin

AU - Kim, Kyuri

AU - Lee, Eun Young

AU - Hillman, Prima F.

AU - Nam, Sang Jip

AU - Lim, Kyung Min

PY - 2024

Y1 - 2024

N2 - Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.

AB - Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.

KW - Anti-ppig-mentary agent

KW - Cyclic adenosine monophosphate

KW - Melanoderm™

KW - Melanogenesis

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KW - Skin pigmentation

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DO - 10.4062/biomolther.2023.103

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JO - Biomolecules and Therapeutics

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ER -

Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression

Abstract

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Keywords

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