TY - JOUR
T1 - Metastasis to the gallbladder
T2 - A single-center experience of 20 cases in South Korea
AU - Yoon, Won Jae
AU - Yoon, Yong Bum
AU - Kim, Youn Joo
AU - Ryu, Ji Kon
AU - Kim, Yong Tae
PY - 2009
Y1 - 2009
N2 - AIM: To evaluate the clinicopathologic characteristics of patients with metastases to the gallbladder (MGBs). METHODS: We performed a single-center retrospective study of 20 patients with MGBs diagnosed pathologically from 1999 to 2007. RESULTS: Among 417 gallbladder (GB) malignancies, 20 (4.8%) were MGBs. The primary malignancies originated from the stomach (n = 8), colorectum (n = 3), liver (n = 2), kidney (n = 2), skin (n = 2), extrahepatic bile duct (n = 1), uterine cervix (n = 1), and appendix (n = 1). Twelve patients were diagnosed metachronously, presenting with cholecystitis (n = 4), abdominal pain (n = 2), jaundice (n = 1), weight loss (n = 1), and serum CA 19-9 elevation (n = 1); five patients were asymptomatic. The median survival after the diagnosis of MGB was 8.7 mo. On Cox regression analysis, R0 resection was the only factor associated with a prolonged survival [hazard ratio (HR): 0.01, P = 0.002]; presentation with cholecystitis was associated with poor survival (HR: 463.27, P = 0.006). CONCLUSION: MGBs accounted for 4.8% of all pathologically diagnosed GB malignancies. The most common origin was the stomach. The median survival of MGB was 8.7 mo.
AB - AIM: To evaluate the clinicopathologic characteristics of patients with metastases to the gallbladder (MGBs). METHODS: We performed a single-center retrospective study of 20 patients with MGBs diagnosed pathologically from 1999 to 2007. RESULTS: Among 417 gallbladder (GB) malignancies, 20 (4.8%) were MGBs. The primary malignancies originated from the stomach (n = 8), colorectum (n = 3), liver (n = 2), kidney (n = 2), skin (n = 2), extrahepatic bile duct (n = 1), uterine cervix (n = 1), and appendix (n = 1). Twelve patients were diagnosed metachronously, presenting with cholecystitis (n = 4), abdominal pain (n = 2), jaundice (n = 1), weight loss (n = 1), and serum CA 19-9 elevation (n = 1); five patients were asymptomatic. The median survival after the diagnosis of MGB was 8.7 mo. On Cox regression analysis, R0 resection was the only factor associated with a prolonged survival [hazard ratio (HR): 0.01, P = 0.002]; presentation with cholecystitis was associated with poor survival (HR: 463.27, P = 0.006). CONCLUSION: MGBs accounted for 4.8% of all pathologically diagnosed GB malignancies. The most common origin was the stomach. The median survival of MGB was 8.7 mo.
KW - Biliary tract neoplasms
KW - Gallbladder
KW - Gastrointestinal neoplasms
KW - Neoplasm metastasis
KW - Neoplasms
UR - http://www.scopus.com/inward/record.url?scp=73449109112&partnerID=8YFLogxK
U2 - 10.3748/wjg.15.4806
DO - 10.3748/wjg.15.4806
M3 - Article
C2 - 19824115
AN - SCOPUS:73449109112
SN - 1007-9327
VL - 15
SP - 4806
EP - 4809
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 38
ER -