Metal-Free Synthesis of N-Aryl-Substituted Azacycles from Cyclic Ethers Using POCl3

Minh Thanh La, Soosung Kang, Hee Kwon Kim

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A facile method for the synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers has been developed. In this study, arylamines were treated with cyclic ethers in the presence of POCl3 and DBU to provide five- A nd six-membered azacycles. Using this method, various azacycloalkanes, isoindolines, and tetrahydroisoquinolines were prepared in high yields. This synthetic method offers an efficient approach to the production of azacycles from cyclic ethers.

Original languageEnglish
Pages (from-to)6689-6696
Number of pages8
JournalJournal of Organic Chemistry
Volume84
Issue number11
DOIs
StatePublished - 7 Jun 2019

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