Abstract
A facile method for the synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers has been developed. In this study, arylamines were treated with cyclic ethers in the presence of POCl3 and DBU to provide five- A nd six-membered azacycles. Using this method, various azacycloalkanes, isoindolines, and tetrahydroisoquinolines were prepared in high yields. This synthetic method offers an efficient approach to the production of azacycles from cyclic ethers.
Original language | English |
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Pages (from-to) | 6689-6696 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 84 |
Issue number | 11 |
DOIs | |
State | Published - 7 Jun 2019 |
Bibliographical note
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