Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Kei Anne Baritugo; Hee Taek Kim; Yokimiko David; Jong il Choi; Soon Ho Hong; Ki Jun Jeong; Jong Hyun Choi; Jeong Chan Joo; Si Jae Park

doi:10.1007/s00253-018-8896-6

Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Kei Anne Baritugo, Hee Taek Kim, Yokimiko David, Jong il Choi, Soon Ho Hong, Ki Jun Jeong, Jong Hyun Choi, Jeong Chan Joo, Si Jae Park

Department of Chemical Engineering & Materials Science

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2–C6 platform chemicals using recombinant C. glutamicum.

Original language	English
Pages (from-to)	3915-3937
Number of pages	23
Journal	Applied Microbiology and Biotechnology
Volume	102
Issue number	9
DOIs	https://doi.org/10.1007/s00253-018-8896-6
State	Published - 1 May 2018

Bibliographical note

Funding Information:
This work was supported by the Mid-career Researcher Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2016R1A2B4008707), a basic research grant from the KRIBB, and the Lignin Biorefinery from MSIT through the NRF of Korea (NRF-2017M1A2A2087634). Please contact corresponding author for any data requests.

Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

Bio-based chemicals
Corynebacterium glutamicum
Metabolic engineering
Microbial cell factory
Plasmid vectors
Promoters

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00253-018-8896-6

Cite this

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title = "Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery",

abstract = "Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2–C6 platform chemicals using recombinant C. glutamicum.",

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note = "Funding Information: This work was supported by the Mid-career Researcher Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2016R1A2B4008707), a basic research grant from the KRIBB, and the Lignin Biorefinery from MSIT through the NRF of Korea (NRF-2017M1A2A2087634). Please contact corresponding author for any data requests. Publisher Copyright: {\textcopyright} 2018, Springer-Verlag GmbH Germany, part of Springer Nature.",

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AU - Hong, Soon Ho

AU - Jeong, Ki Jun

AU - Choi, Jong Hyun

AU - Joo, Jeong Chan

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N2 - Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2–C6 platform chemicals using recombinant C. glutamicum.

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Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Abstract

Bibliographical note

Keywords

UN SDGs

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