Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Kei Anne Baritugo, Hee Taek Kim, Yokimiko David, Jong il Choi, Soon Ho Hong, Ki Jun Jeong, Jong Hyun Choi, Jeong Chan Joo, Si Jae Park

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2–C6 platform chemicals using recombinant C. glutamicum.

Original languageEnglish
Pages (from-to)3915-3937
Number of pages23
JournalApplied Microbiology and Biotechnology
Volume102
Issue number9
DOIs
StatePublished - 1 May 2018

Keywords

  • Bio-based chemicals
  • Corynebacterium glutamicum
  • Metabolic engineering
  • Microbial cell factory
  • Plasmid vectors
  • Promoters

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