Meta-analysis of the impact of thioprine S-methyltransferase polymorphisms on the tolerable 6-mercaptopurine dose considering initial dose and ethnic difference

Myeong Gyu Kim, Minoh Ko, In Wha Kim, Jung Mi Oh

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A meta-analysis was conducted to decide whether to reduce an initial 6-mercaptopurine (6-MP) dose in TPMT heterozygote in the case of an initial 6-MP dose of,75 mg/m2/d and to compare the tolerable 6-MP dose among different ethnic groups. The study was undertaken according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The differences in mean values of the tolerable 6-MP dose were calculated by using Comprehensive Meta-Analysis version 3. The results of the meta-analysis indicated that the tolerable 6-MP dose was significantly lower in the TPMT heterozygote group (difference in mean values =11.729, 95% confidence interval =7.617-15.842, P,0.001) even when the initial 6-MP dose was,75 mg/m2/d. The TPMT*3C allele-dominant ethnic group (Asian) needed less reduction in mean 6-MP dose in comparison to the TPMT*3A allele-dominant ethnic group (Caucasian, Mediterranean, South American) (difference in mean values =8.884 vs 15.324). In conclusion, the initial 6-MP dose needs to be reduced in TPMT heterozygote when compared to the wild-type, and ethnic difference might influence the tolerable 6-MP dose in TPMT heterozygotes.

Original languageEnglish
Pages (from-to)7133-7139
Number of pages7
JournalOncoTargets and Therapy
Volume9
DOIs
StatePublished - 18 Nov 2016

Keywords

  • 6-mercaptopurine
  • Meta-analysis
  • Polymorphism
  • Thiopurine S-methyltransferase

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