Meta-analysis of genome-wide SNP- A nd pathway-based associations for facets of neuroticism

Song E. Kim; Han Na Kim; Yeo Jun Yun; Seong Gu Heo; Juhee Cho; Min Jung Kwon; Yoosoo Chang; Seungho Ryu; Hocheol Shin; Chol Shin; Nam H. Cho; Yeon Ah Sung; Hyung Lae Kim

doi:10.1038/jhg.2017.61

Meta-analysis of genome-wide SNP- A nd pathway-based associations for facets of neuroticism

Song E. Kim, Han Na Kim, Yeo Jun Yun, Seong Gu Heo, Juhee Cho, Min Jung Kwon, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Chol Shin, Nam H. Cho, Yeon Ah Sung, Hyung Lae Kim

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet. Six neuroticism facets (N1: Anxiety, N2: Angry hostility, N3: Depression, N4: Self-consciousness, N5: Impulsivity and N6: Vulnerability) were assessed using the Korean version of the Revised NEO Personality Inventory. In the single-nucleotide polymorphism-based analysis, results showed genome-wide significance for N2 within the MIR548H3 gene (rs1360001, P=4.14 × 10 â '9). Notable genes with suggestive associations (P<1.0 × 10 â '6) were ITPR1 for N1, WNT7A for N2, FGF10 and FHIT for N3, DDR1 for N4, VGLL4 for N5 and PTPRD for N6. In the pathway-based analysis, the axon guidance pathway was identified to be associated with multiple facets of neuroticism (N2, N4 and N6). The focal adhesion and extracellular matrix receptor interaction pathways were significantly associated with N2 and N3. Our findings revealed genetic influences and biological pathways that are associated with facets of neuroticism.

Original language	English
Pages (from-to)	903-909
Number of pages	7
Journal	Journal of Human Genetics
Volume	62
Issue number	10
DOIs	https://doi.org/10.1038/jhg.2017.61
State	Published - 1 Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 The Japan Society of Human Genetics.

Access to Document

10.1038/jhg.2017.61

Cite this

@article{1838280cb9bd4a83980601316078af77,

title = "Meta-analysis of genome-wide SNP- A nd pathway-based associations for facets of neuroticism",

abstract = "Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet. Six neuroticism facets (N1: Anxiety, N2: Angry hostility, N3: Depression, N4: Self-consciousness, N5: Impulsivity and N6: Vulnerability) were assessed using the Korean version of the Revised NEO Personality Inventory. In the single-nucleotide polymorphism-based analysis, results showed genome-wide significance for N2 within the MIR548H3 gene (rs1360001, P=4.14 × 10 {\^a} '9). Notable genes with suggestive associations (P<1.0 × 10 {\^a} '6) were ITPR1 for N1, WNT7A for N2, FGF10 and FHIT for N3, DDR1 for N4, VGLL4 for N5 and PTPRD for N6. In the pathway-based analysis, the axon guidance pathway was identified to be associated with multiple facets of neuroticism (N2, N4 and N6). The focal adhesion and extracellular matrix receptor interaction pathways were significantly associated with N2 and N3. Our findings revealed genetic influences and biological pathways that are associated with facets of neuroticism.",

author = "Kim, {Song E.} and Kim, {Han Na} and Yun, {Yeo Jun} and Heo, {Seong Gu} and Juhee Cho and Kwon, {Min Jung} and Yoosoo Chang and Seungho Ryu and Hocheol Shin and Chol Shin and Cho, {Nam H.} and Sung, {Yeon Ah} and Kim, {Hyung Lae}",

note = "Publisher Copyright: {\textcopyright} 2017 The Japan Society of Human Genetics.",

year = "2017",

month = oct,

day = "1",

doi = "10.1038/jhg.2017.61",

language = "English",

volume = "62",

pages = "903--909",

journal = "Journal of Human Genetics",

issn = "1434-5161",

publisher = "Springer Nature",

number = "10",

}

TY - JOUR

T1 - Meta-analysis of genome-wide SNP- A nd pathway-based associations for facets of neuroticism

AU - Kim, Song E.

AU - Kim, Han Na

AU - Yun, Yeo Jun

AU - Heo, Seong Gu

AU - Cho, Juhee

AU - Kwon, Min Jung

AU - Chang, Yoosoo

AU - Ryu, Seungho

AU - Shin, Hocheol

AU - Shin, Chol

AU - Cho, Nam H.

AU - Sung, Yeon Ah

AU - Kim, Hyung Lae

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet. Six neuroticism facets (N1: Anxiety, N2: Angry hostility, N3: Depression, N4: Self-consciousness, N5: Impulsivity and N6: Vulnerability) were assessed using the Korean version of the Revised NEO Personality Inventory. In the single-nucleotide polymorphism-based analysis, results showed genome-wide significance for N2 within the MIR548H3 gene (rs1360001, P=4.14 × 10 â '9). Notable genes with suggestive associations (P<1.0 × 10 â '6) were ITPR1 for N1, WNT7A for N2, FGF10 and FHIT for N3, DDR1 for N4, VGLL4 for N5 and PTPRD for N6. In the pathway-based analysis, the axon guidance pathway was identified to be associated with multiple facets of neuroticism (N2, N4 and N6). The focal adhesion and extracellular matrix receptor interaction pathways were significantly associated with N2 and N3. Our findings revealed genetic influences and biological pathways that are associated with facets of neuroticism.

AB - Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet. Six neuroticism facets (N1: Anxiety, N2: Angry hostility, N3: Depression, N4: Self-consciousness, N5: Impulsivity and N6: Vulnerability) were assessed using the Korean version of the Revised NEO Personality Inventory. In the single-nucleotide polymorphism-based analysis, results showed genome-wide significance for N2 within the MIR548H3 gene (rs1360001, P=4.14 × 10 â '9). Notable genes with suggestive associations (P<1.0 × 10 â '6) were ITPR1 for N1, WNT7A for N2, FGF10 and FHIT for N3, DDR1 for N4, VGLL4 for N5 and PTPRD for N6. In the pathway-based analysis, the axon guidance pathway was identified to be associated with multiple facets of neuroticism (N2, N4 and N6). The focal adhesion and extracellular matrix receptor interaction pathways were significantly associated with N2 and N3. Our findings revealed genetic influences and biological pathways that are associated with facets of neuroticism.

UR - http://www.scopus.com/inward/record.url?scp=85029863891&partnerID=8YFLogxK

U2 - 10.1038/jhg.2017.61

DO - 10.1038/jhg.2017.61

M3 - Article

C2 - 28615674

AN - SCOPUS:85029863891

SN - 1434-5161

VL - 62

SP - 903

EP - 909

JO - Journal of Human Genetics

JF - Journal of Human Genetics

IS - 10

ER -

Meta-analysis of genome-wide SNP- A nd pathway-based associations for facets of neuroticism

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this