Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy

Xingshu Li; C. yoon Kim; Jeong Min Shin; Dayoung Lee; Gyoungmi Kim; Hyung Min Chung; Ki Sung Hong; Juyoung Yoon

doi:10.1016/j.biomaterials.2018.09.041

Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy

Xingshu Li, C. yoon Kim, Jeong Min Shin, Dayoung Lee, Gyoungmi Kim, Hyung Min Chung, Ki Sung Hong, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Precise targeting with minimal side effects is of particular interest for personalized medicine, although it remains a challenge. Herein, we demonstrate precision photodynamic therapy (PDT) utilizing human mesenchymal stem cells (MSCs) as cellular vehicles to deliver a new activatable photosensitizer (PcS). In vivo real-time optical imaging tests indicated that PcS-loaded MSCs possess excellent tumor-homing properties. More importantly, dye transfer assays confirm that MSCs precisely transfer PcS into human colon cancer cells (HCT116) via the “bystander effect.” Upon localized light irradiation, the growth of intraperitoneal xenograft tumors was significantly inhibited by the photodynamic effect. These findings represent a promising strategy for precise oncotherapy.

Original language	English
Pages (from-to)	18-26
Number of pages	9
Journal	Biomaterials
Volume	187
DOIs	https://doi.org/10.1016/j.biomaterials.2018.09.041
State	Published - Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

Activatable photosensitizer
Mesenchymal stem cells
Photodynamic therapy
Precision medicine
Tumor targeting

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10.1016/j.biomaterials.2018.09.041

Cite this

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title = "Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy",

abstract = "Precise targeting with minimal side effects is of particular interest for personalized medicine, although it remains a challenge. Herein, we demonstrate precision photodynamic therapy (PDT) utilizing human mesenchymal stem cells (MSCs) as cellular vehicles to deliver a new activatable photosensitizer (PcS). In vivo real-time optical imaging tests indicated that PcS-loaded MSCs possess excellent tumor-homing properties. More importantly, dye transfer assays confirm that MSCs precisely transfer PcS into human colon cancer cells (HCT116) via the “bystander effect.” Upon localized light irradiation, the growth of intraperitoneal xenograft tumors was significantly inhibited by the photodynamic effect. These findings represent a promising strategy for precise oncotherapy.",

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author = "Xingshu Li and Kim, {C. yoon} and Shin, {Jeong Min} and Dayoung Lee and Gyoungmi Kim and Chung, {Hyung Min} and Hong, {Ki Sung} and Juyoung Yoon",

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AU - Li, Xingshu

AU - Kim, C. yoon

AU - Shin, Jeong Min

AU - Lee, Dayoung

AU - Kim, Gyoungmi

AU - Chung, Hyung Min

AU - Hong, Ki Sung

AU - Yoon, Juyoung

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AB - Precise targeting with minimal side effects is of particular interest for personalized medicine, although it remains a challenge. Herein, we demonstrate precision photodynamic therapy (PDT) utilizing human mesenchymal stem cells (MSCs) as cellular vehicles to deliver a new activatable photosensitizer (PcS). In vivo real-time optical imaging tests indicated that PcS-loaded MSCs possess excellent tumor-homing properties. More importantly, dye transfer assays confirm that MSCs precisely transfer PcS into human colon cancer cells (HCT116) via the “bystander effect.” Upon localized light irradiation, the growth of intraperitoneal xenograft tumors was significantly inhibited by the photodynamic effect. These findings represent a promising strategy for precise oncotherapy.

KW - Activatable photosensitizer

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KW - Tumor targeting

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Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy

Abstract

Bibliographical note

Keywords

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