@article{40310c1af5e147e1ae68cd2b00567995,
title = "Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy",
abstract = "Precise targeting with minimal side effects is of particular interest for personalized medicine, although it remains a challenge. Herein, we demonstrate precision photodynamic therapy (PDT) utilizing human mesenchymal stem cells (MSCs) as cellular vehicles to deliver a new activatable photosensitizer (PcS). In vivo real-time optical imaging tests indicated that PcS-loaded MSCs possess excellent tumor-homing properties. More importantly, dye transfer assays confirm that MSCs precisely transfer PcS into human colon cancer cells (HCT116) via the “bystander effect.” Upon localized light irradiation, the growth of intraperitoneal xenograft tumors was significantly inhibited by the photodynamic effect. These findings represent a promising strategy for precise oncotherapy.",
keywords = "Activatable photosensitizer, Mesenchymal stem cells, Photodynamic therapy, Precision medicine, Tumor targeting",
author = "Xingshu Li and Kim, {C. yoon} and Shin, {Jeong Min} and Dayoung Lee and Gyoungmi Kim and Chung, {Hyung Min} and Hong, {Ki Sung} and Juyoung Yoon",
note = "Funding Information: J. Y. is thankful for support from the National Research Foundation of Korea ( NRF ), which was funded by the Korean government ( MSIP ) (No. 2012R1A3A2048814 ). K. S. H.and H. M. C. are thankful for the support from the Ministry of Health and Welfare ( HI14C3365 ) and the Basic Science Research Program through the National Research Foundation of Korea ( NRF ), which was funded by the Ministry of Education ( NRF-2016R1D1A3B03932998 ). Funding Information: J. Y. is thankful for support from the National Research Foundation of Korea (NRF), which was funded by the Korean government (MSIP) (No. 2012R1A3A2048814). K. S. H.and H. M. C. are thankful for the support from the Ministry of Health and Welfare (HI14C3365) and the Basic Science Research Program through the National Research Foundation of Korea (NRF), which was funded by the Ministry of Education (NRF-2016R1D1A3B03932998). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = dec,
doi = "10.1016/j.biomaterials.2018.09.041",
language = "English",
volume = "187",
pages = "18--26",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",
}