Meroindenon and Merochlorins e and F, Antibacterial Meroterpenoids from a Marine-Derived Sediment Bacterium of the Genus Streptomyces

Min Ji Ryu, Sunghoon Hwang, Sojeong Kim, Inho Yang, Dong Chan Oh, Sang Jip Nam, William Fenical

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38 Scopus citations

Abstract

Meroterpenoids, meroindenon (1) and merochlorins E (2) and F (3), were isolated from a marine-derived bacterium belonging to the genus Streptomyces. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds 1-3 possess a tetrahydroxynaphthalene core and a C15-isoprene unit. Compounds 2 and 3 exhibited strong antibacterial activities against B. subtilis, K. rhizophila, and S. aureus, with a range of MIC values from 1 to 2 μg/mL.

Original languageEnglish
Pages (from-to)5779-5783
Number of pages5
JournalOrganic Letters
Volume21
Issue number15
DOIs
StatePublished - 2 Aug 2019

Bibliographical note

Funding Information:
The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning under Grant No. NRF-2017R1D1A1B03028172 (to S.-J.N.) and in part by the US National Cancer Institute (NIH) under Grant No. R37 CA044848 (to W.F.).

Publisher Copyright:
Copyright © 2019 American Chemical Society.

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