Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

Seokwoo Lee; Yun Mi Lee; Hyun Ji Lee; Hongjun Jeon; Hyukjin Lee; Dongyun Shin; Sanghee Kim

doi:10.1002/ajoc.201900342

Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

Seokwoo Lee
, Yun Mi Lee
, Hyun Ji Lee
, Hongjun Jeon
, Hyukjin Lee
, Dongyun Shin
, Sanghee Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu⁺. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.

Original language	English
Pages (from-to)	1713-1717
Number of pages	5
Journal	Asian Journal of Organic Chemistry
Volume	8
Issue number	9
DOIs	https://doi.org/10.1002/ajoc.201900342
State	Published - 1 Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

Ceramide
Click chemistry
Liposomes
Membrane fusion
Triazole

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10.1002/ajoc.201900342

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abstract = "An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.",

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AU - Lee, Hyun Ji

AU - Jeon, Hongjun

AU - Lee, Hyukjin

AU - Shin, Dongyun

AU - Kim, Sanghee

PY - 2019/9/1

Y1 - 2019/9/1

N2 - An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.

AB - An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.

KW - Ceramide

KW - Click chemistry

KW - Liposomes

KW - Membrane fusion

KW - Triazole

UR - https://www.scopus.com/pages/publications/85069649351

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M3 - Article

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JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

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ER -

Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

Abstract

Bibliographical note

Keywords

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