Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

Seokwoo Lee, Yun Mi Lee, Hyun Ji Lee, Hongjun Jeon, Hyukjin Lee, Dongyun Shin, Sanghee Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.

Original languageEnglish
Pages (from-to)1713-1717
Number of pages5
JournalAsian Journal of Organic Chemistry
Volume8
Issue number9
DOIs
StatePublished - 1 Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • Ceramide
  • Click chemistry
  • Liposomes
  • Membrane fusion
  • Triazole

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