An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.
Bibliographical noteFunding Information:
This work was supported by the Pioneer Research Center Program (2014M3C1A3054139) of the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP). We are grateful to the Research Institute of Pharmaceutical Sciences at Seoul National University for providing some experimental equipment.
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- Click chemistry
- Membrane fusion