Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

Seokwoo Lee; Yun Mi Lee; Hyun Ji Lee; Hongjun Jeon; Hyukjin Lee; Dongyun Shin; Sanghee Kim

doi:10.1002/ajoc.201900342

Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

Seokwoo Lee, Yun Mi Lee, Hyun Ji Lee, Hongjun Jeon, Hyukjin Lee, Dongyun Shin, Sanghee Kim

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu⁺. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.

Original language	English
Pages (from-to)	1713-1717
Number of pages	5
Journal	Asian Journal of Organic Chemistry
Volume	8
Issue number	9
DOIs	https://doi.org/10.1002/ajoc.201900342
State	Published - 1 Sep 2019

Bibliographical note

Funding Information:
This work was supported by the Pioneer Research Center Program (2014M3C1A3054139) of the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP). We are grateful to the Research Institute of Pharmaceutical Sciences at Seoul National University for providing some experimental equipment.

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

Ceramide
Click chemistry
Liposomes
Membrane fusion
Triazole

Access to Document

10.1002/ajoc.201900342

Cite this

@article{8674b399a8ea496ca82e44592385ef28,

title = "Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface",

abstract = "An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.",

keywords = "Ceramide, Click chemistry, Liposomes, Membrane fusion, Triazole",

author = "Seokwoo Lee and Lee, {Yun Mi} and Lee, {Hyun Ji} and Hongjun Jeon and Hyukjin Lee and Dongyun Shin and Sanghee Kim",

note = "Funding Information: This work was supported by the Pioneer Research Center Program (2014M3C1A3054139) of the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP). We are grateful to the Research Institute of Pharmaceutical Sciences at Seoul National University for providing some experimental equipment. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

month = sep,

day = "1",

doi = "10.1002/ajoc.201900342",

language = "English",

volume = "8",

pages = "1713--1717",

journal = "Asian Journal of Organic Chemistry",

issn = "2193-5807",

publisher = "Wiley - VCH Verlag GmbH & CO. KGaA",

number = "9",

}

TY - JOUR

T1 - Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

AU - Lee, Seokwoo

AU - Lee, Yun Mi

AU - Lee, Hyun Ji

AU - Jeon, Hongjun

AU - Lee, Hyukjin

AU - Shin, Dongyun

AU - Kim, Sanghee

N1 - Funding Information: This work was supported by the Pioneer Research Center Program (2014M3C1A3054139) of the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP). We are grateful to the Research Institute of Pharmaceutical Sciences at Seoul National University for providing some experimental equipment. Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/9/1

Y1 - 2019/9/1

N2 - An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.

AB - An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.

KW - Ceramide

KW - Click chemistry

KW - Liposomes

KW - Membrane fusion

KW - Triazole

UR - http://www.scopus.com/inward/record.url?scp=85069649351&partnerID=8YFLogxK

U2 - 10.1002/ajoc.201900342

DO - 10.1002/ajoc.201900342

M3 - Article

AN - SCOPUS:85069649351

SN - 2193-5807

VL - 8

SP - 1713

EP - 1717

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 9

ER -

Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this