Melanocytotoxic chemicals and their toxic mechanisms

Minjeong Kim, Kyung Min Lim

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Melanocyte cell death can lead to various melanocyte-related skin diseases including vitiligo and leukoderma. Melanocytotoxic chemicals are one of the most well-known causes of nongenetic melanocyte-related diseases, which induce melanocyte cell death through apoptosis. Various chemicals used in cosmetics, medicine, industry and food additives are known to induce melanocyte cell death, which poses a significant risk to the health of consumers and industrial workers. This review summarizes recently reported melanocytotoxic chemicals and their mechanisms of toxicity in an effort to provide insight into the development of safer chemicals.

Original languageEnglish
Pages (from-to)417-435
Number of pages19
JournalToxicological Research
Issue number4
StatePublished - Oct 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s) under exclusive licence to Korean Society of Toxicology.


  • Leukoderma
  • Melanocyte
  • Melanocytotoxic chemicals
  • Pigmentation disease
  • Vitiligo


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