Medication-related osteonecrosis of the maxilla: Prognosis of oral surgery combined with endoscopic sinus surgery

Jung Hyun Park, Angenine Marie Alfafara, Young Long Park, Jung Ho Bae, Sun Jong Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objectives: To evaluate the effect of functional endoscopic sinus surgery (FESS) on the resolution of maxillary medication-related osteonecrosis of the jaw (MRONJ). Patients and Methods: This study included 62 patients diagnosed with MRONJ in the maxillary posterior area with or without maxillary sinusitis (MS). All patients underwent oral surgery. The concomitant MS was evaluated, and if indicated, FESS was performed on the same operation. Follow-up included clinical and radiological examinations at 4 months postoperation. Results: Of the 62 patients, 24 (38.7%) showed no evidence of MS and 38 (61.3%) showed MS. Advanced MRONJ (stage 3), which has bony destruction of the sinus floor and signs of MS according to its definition, was seen in 27 patients (43.5%). In stage 3 MRONJ, patients with combined treatment of oral surgery and FESS compared to those treated with oral surgery alone showed higher percentage of resolution (84.2%, 37.5%, respectively) at 4 months postoperatively, and the results were statistically significant. Conclusion: Simultaneous management of MRONJ and sinusitis with combined treatment of oral surgery and FESS for the treatment of maxillary MRONJ can be an effective method, especially for advanced cases, to address its associated lesions.

Original languageEnglish
Pages (from-to)962-969
Number of pages8
JournalOral Diseases
Volume27
Issue number4
DOIs
StatePublished - May 2021

Keywords

  • endoscopic sinus surgery
  • maxilla
  • medication-related osteonecrosis of the jaw
  • sinusitis

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