Mechanisms of the effects of acidosis and hypokalemia on renal ammonia metabolism

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Renal ammonia metabolism is the predominant component of net acid excretion and new bicarbonate generation. Renal ammonia metabolism is regulated by acid-base balance. Both acute and chronic acid loads enhance ammonia production in the proximal tubule and secretion into the urine. In contrast, alkalosis reduces ammoniagenesis. Hypokalemia is a common electrolyte disorder that significantly increases renal ammonia production and excretion, despite causing metabolic alkalosis. Although the net effects of hypokalemia are similar to metabolic acidosis, molecular mechanisms of renal ammonia production and transport have not been well understood. This mini review summarizes recent findings regarding renal ammonia metabolism in response to chronic hypokalemia.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalElectrolyte and Blood Pressure
Issue number2
StatePublished - Dec 2011


  • Acids
  • Ammonia
  • Hypokalemia
  • Kidney


Dive into the research topics of 'Mechanisms of the effects of acidosis and hypokalemia on renal ammonia metabolism'. Together they form a unique fingerprint.

Cite this