TY - JOUR
T1 - Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix
AU - Wang, Zhixiong
AU - Itoh, Yoshiaki
AU - Hosaka, Yoshifumi
AU - Kobayashi, Ichiro
AU - Nakano, Yoshihisa
AU - Maeda, Isamu
AU - Umeda, Fusako
AU - Yamakawa, Junji
AU - Nishimine, Mari
AU - Suenobu, Tomoyoshi
AU - Fukuzumi, Shunichi
AU - Kawase, Masaya
AU - Yagi, Kiyohito
PY - 2003
Y1 - 2003
N2 - The possible application of polyhydroxyalkanoate (PHA) in transdermal drug delivery systems (TDDSs) for tamsulosin was previously reported. PHAs containing the drugs, ketoprofen, clonidine and tamsulosin showed good adhesiveness to the skin model used, that is, shed snake skin, and dispersed well all model drugs tested. The model drugs hardly permeated through snake skin in solution form. However, these drugs permeated well through snake skin from the PHA matrix. It was previously reported that the addition of a dendrimer, a polymeric permeation enhancer, is effective for the TDDS for tamsulosin to establish an effective clinical TDDS. The effect of dendrimer addition was examined in TDDSs for ketoprofen and clonidine. The dendrimer added did not show an enhancement effect on the TDDSs for the two drugs. To investigate the mechanism of the enhancement effect of a dendrimer on the tamsulosin TDDS, X-ray analyses were performed. With dendrimer addition, drug crystallization in PHA was promoted. The crystal in PHA had highly ordered and changed its space group. These findings are very important for exploiting high-performance PHA-based TDDSs.
AB - The possible application of polyhydroxyalkanoate (PHA) in transdermal drug delivery systems (TDDSs) for tamsulosin was previously reported. PHAs containing the drugs, ketoprofen, clonidine and tamsulosin showed good adhesiveness to the skin model used, that is, shed snake skin, and dispersed well all model drugs tested. The model drugs hardly permeated through snake skin in solution form. However, these drugs permeated well through snake skin from the PHA matrix. It was previously reported that the addition of a dendrimer, a polymeric permeation enhancer, is effective for the TDDS for tamsulosin to establish an effective clinical TDDS. The effect of dendrimer addition was examined in TDDSs for ketoprofen and clonidine. The dendrimer added did not show an enhancement effect on the TDDSs for the two drugs. To investigate the mechanism of the enhancement effect of a dendrimer on the tamsulosin TDDS, X-ray analyses were performed. With dendrimer addition, drug crystallization in PHA was promoted. The crystal in PHA had highly ordered and changed its space group. These findings are very important for exploiting high-performance PHA-based TDDSs.
KW - Dendrimer
KW - Enhancing effect
KW - Polyhydroxyalkanoate
KW - Transdermal drug delivery
KW - X-ray diffraction
UR - http://www.scopus.com/inward/record.url?scp=0346494969&partnerID=8YFLogxK
U2 - 10.1263/jbb.96.537
DO - 10.1263/jbb.96.537
M3 - Article
AN - SCOPUS:0346494969
SN - 1389-1723
VL - 96
SP - 537
EP - 540
JO - Journal of Bioscience and Bioengineering
JF - Journal of Bioscience and Bioengineering
IS - 6
ER -