@inproceedings{1102a02ab5e4482db3b62c4c4cae1034,
title = "Mechanical cell lysis results of a sample preparation module for functional genomics",
abstract = "Mechanical cell lysis is demonstrated within a microfabricated sample preparation module that would assist functional genomics and point-of-care diagnostics. The sample preparation module is proposed as a component of a vertically integrated system with RT-PCR and capillary gel electrophoresis modules. Cell lysis is conducted within the module using a micro-barbed mechanical filter within microfluidic channels. Cell behavior within the lysis filter is qualitatively described. The filter is microfabricated using a modified DRIE process that enhances the scalloping effect to create sub-micrometer scale barbs. An integrated mRNA affinity chamber is also developed with ssDNA immobilized on a silicon surface using a self-assembled monolayer linker.",
author = "{Di Carlo}, D. and Lee, {L. P.}",
note = "Publisher Copyright: {\textcopyright} 2002 IEEE.; 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology ; Conference date: 02-05-2002 Through 04-05-2002",
year = "2002",
doi = "10.1109/MMB.2002.1002399",
language = "English",
series = "2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "527--530",
editor = "David Beebe and Andre Dittmar",
booktitle = "2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings",
}